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Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease
TLDR
It is reported that minocycline delays disease progression, inhibits casp enzyme-1 and caspase-3 mRNA upregulation, and decreases inducible nitric oxide synthetase activity, in the R6/2 mouse model of Huntington disease. Expand
Activation and Cleavage of Caspase-3 in Apoptosis Induced by Experimental Cerebral Ischemia
TLDR
The existence of a time-dependent evolution of ischemic injury characterized by the close correspondence between caspase-like enzyme activation and an associated increase in immunoreactive product (caspases-3p20) beginning at or before reperfusion and followed several hours later by morphological and biochemical features of apoptosis is suggested. Expand
Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage.
TLDR
Z-VAD.FMK protected against alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate-induced or to a lesser extent N- methyl-D-aspartate- induced excitotoxic brain damage and provided therapeutic targets for stroke and neurodegenerative brain damage. Expand
5-HT Receptor Regulation of Neurotransmitter Release
TLDR
This review focuses on the function of presynaptic 5-hydroxytryptamine (5-HT) heteroreceptors on axon terminals of central cholinergic, dopaminergic, noradrenergic, or GABAergic neurons and the role of GABAergic interneurons expressing 5-HT heteroreCEPTors in the regulation of acetylcholine, dopamine, or nor adrenaline release. Expand
Histamine inhibits dopamine release in the mouse striatum via presynaptic H3 receptors
TLDR
The dopaminergic nerve terminals in the mouse striatum are endowed with presynaptic H3 receptors, and simultaneous blockade of dopamine autoreceptors increases the extent of the H3 receptor-mediated inhibition of dopamine release. Expand
Inhibition of neuronal Ca2+ influx by gabapentin and pregabalin in the human neocortex
TLDR
Gabapentin and pregabalin produced concentration-dependent inhibitions of the K(+)-induced [Ca(2+)](i) increase in fura-2-loaded human neocortical synaptosomes, consistent with the potency of these drugs to inhibit [(3)H]-gabapentin binding to human neocortsical membranes. Expand
Neuroprotective effects of atorvastatin against glutamate‐induced excitotoxicity in primary cortical neurones
TLDR
Atorvastatin exerts specific anti‐excitotoxic effects independent of 3‐hydroxy‐3‐methylglutaryl‐CoA reductase inhibition, which has potential therapeutic implications. Expand
Effects of selective h5-HT1B (SB-216641) and h5-HT1D (BRL-15572) receptor ligands on guinea-pig and human 5-HT auto- and heteroreceptors
TLDR
In conclusion, SB-216641 behaves as a preferential antagonist at native human 5-HT1B receptors and BRL-15572 as a Preferential antagonists at nativehuman 5- HT1D receptors are clearly useful tools for the differentiation between human5-HT 1B and 5-ht1D receptor in functional studies. Expand
Neuroprotective effects of gelsolin during murine stroke.
TLDR
It is shown that gelsolin-null neurons have enhanced cell death and rapid, sustained elevation of Ca2+ levels following glucose/oxygen deprivation, as well as augmented cytosolic Ca2- levels in nerve terminals following depolarization in vitro, which may be neuroprotective during stroke. Expand
Metaplasticity of Mossy Fiber Synaptic Transmission Involves Altered Release Probability
TLDR
It is suggested that lasting changes in neurotransmitter release probability caused by neuronal activity may be a powerful mechanism for metaplasticity that modulates both short- and long-term plasticity in the mossy fiber-CA3 synapse after status epilepticus. Expand
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