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A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.
- G. Bolger, T. Michaeli, +6 authors K. Ferguson
- Biology, Medicine
- Molecular and cellular biology
- 1 October 1993
We have isolated cDNAs for four human genes (DPDE1 through DPDE4) closely related to the dnc learning and memory locus of Drosophila melanogaster. The deduced amino acid sequences of the Drosophila… Expand
Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae.
- T. Michaeli, T. J. Bloom, +6 authors M. Wigler
- Medicine, Biology
- The Journal of biological chemistry
- 15 June 1993
We have established a highly sensitive functional screen for the isolation of cDNAs encoding cAMP phosphodiesterases (PDEs) by complementation of defects in a Saccharomyces cerevisiae strain lacking… Expand
Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase.
Human cGMP-binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase (PDE5A) cDNAs were isolated. A 3.1-kb composite DNA sequence assembled from overlapping cDNAs encodes an 875-amino-acid… Expand
Variation in protein abundance profiles in the M. semitendinosus of lambs bred from sires selected on the basis of growth and muscling potential
Relative abundance of proteins localised in the nuclear-enriched, total cell membrane and cytosolic fractions of the semitendinosus muscle was compared between lambs bred from control (C), high… Expand
cerevisiae Saccharomyces Function in the Yeast RAS Studies of
Molecular and Phenotypic Analysis of Cap a Regulatory Element Involved in Mediating Both Ras Action and Amino Acid Balance
Comparative proteomics : Identifying novel proteins in the winemaking strain Saccharomyces cerevisiae
Proton-induced nucleon knockout from polarized 3He at 290 MeV
Abstract A novel polarized 3 He gas target has been used to measure spin observables for ( p ,2 p ) and ( p , pn ) nucleon knockout in quasielastic kinematics at 290 MeV. Comparisons with PWIA… Expand