Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host.
APR-induced alterations initially protect the host from the harmful effects of bacteria, viruses, and parasites, however, if prolonged, these changes in the structure and function of lipoproteins will contribute to atherogenesis.
Lipids, lipoproteins, triglyceride clearance, and cytokines in human immunodeficiency virus infection and the acquired immunodeficiency syndrome.
- C. Grunfeld, M. Pang, W. Doerrler, J. Shigenaga, P. Jensen, K. Feingold
- Medicine, BiologyJournal of Clinical Endocrinology and Metabolism
- 1 May 1992
Infection causes disturbances in lipid metabolism that may be mediated by cytokines. Therefore we studied plasma lipids, lipoproteins, triglyceride (TG) metabolism, and serum cytokines in three…
Lipopenia and Skin Barrier Abnormalities in DGAT2-deficient Mice*
Dgat2-deficient mice are lipopenic and die soon after birth, apparently from profound reductions in substrates for energy metabolism and from impaired permeability barrier function in the skin, supporting the hypothesis that the two enzymes play fundamentally different roles in mammalian triglyceride metabolism.
Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters.
Induction of leptin during the host response to infection may contribute to the anorexia of infection, as assessed by immuknoprecipitation and Western blotting.
Infection and inflammation-induced proatherogenic changes of lipoproteins.
The changes of lipoproteins during infection and inflammation are reviewed with a focus on those that are potentially proatherogenic, which may contribute to the link between infection/inflammation and atherosclerosis.
Leptin regulation of the immune response and the immunodeficiency of malnutrition 1
Low leptin levels occurring during starvation mediate the neuroendocrine and immune dysfunction of starvation, and may represent a protective component of the host response to inflammation.
The Acute Phase Response Is Associated with Retinoid X Receptor Repression in Rodent Liver*
- A. Beigneux, A. Moser, J. Shigenaga, C. Grunfeld, K. Feingold
- Biology, MedicineJournal of Biological Chemistry
- 26 May 2000
It is demonstrated that lipopolysaccharide (LPS) induces a rapid, dose-dependent decrease in RXRα, RXRβ, and RXRγ proteins in hamster liver, and increased RNA degradation is likely responsible for the repression of RXR.
pH directly regulates epidermal permeability barrier homeostasis, and stratum corneum integrity/cohesion.
- J. Hachem, D. Crumrine, J. Fluhr, B. Brown, K. Feingold, P. Elias
- BiologyJournal of Investigative Dermatology
- 1 August 2003
It is demonstrated unequivocally that stratum corneum neutralization alone provokes stratumCorneum functional abnormalities, including aberrant permeability barrier homeostasis and decreased stratum Corneum integrity/cohesion, as well as the mechanisms responsible for these abnormalities.
Diabetes-related complications, glycemic control, and falls in older adults
In older diabetic adults, reducing diabetes-related complications may prevent falls, and achieving lower A1C levels with oral hypoglycemic medications was not associated with more frequent falls, but, among those using insulin, A 1C ≤6% increased fall risk.