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Reduction of protein sequence complexity by residue grouping.
It is well known that there are some similarities among various naturally occurring amino acids. Thus, the complexity in protein systems could be reduced by sorting these amino acids withExpand
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The number of protein folds and their distribution over families in nature
Currently, of the 106 known protein sequences, only about 104 structures have been solved. Based on homologies and similarities, proteins are grouped into different families in which each has aExpand
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What is the minimum number of letters required to fold a protein?
  • K. Fan, W. Wang
  • Biology, Medicine
  • Journal of molecular biology
  • 9 May 2003
Experimental studies have shown that the full sequence complexity of naturally occurring proteins is not required to generate rapidly folding and functional proteins, i.e. proteins can be designedExpand
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Folding of lattice protein chains with modified Gō potential
Abstract:We propose a modified Gō model in which the pairwise interaction energies vary as local environment changes. The stability difference between the surface and the core is also well consideredExpand
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The validity of complexity simplifications for proteins with different structural features may be different. In this paper, the simplification for proteins is studied using the ratios of successfulExpand
  • 5
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Modeling two-state cooperativity in protein folding.
  • K. Fan, J. Wang, W. Wang
  • Physics, Biology
  • Physical review. E, Statistical, nonlinear, and…
  • 19 March 2001
A protein model with the pairwise interaction energies varying as the local environment changes, i.e., including some kind of collective effect between the contacts, is proposed. Lattice Monte CarloExpand
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Kinetic transition in model proteins with a denatured native spinodal.
  • J. Wang, K. Fan, W. Wang
  • Materials Science, Medicine
  • Physical review. E, Statistical, nonlinear, and…
  • 1 April 2002
The relaxation kinetics of three-dimensional lattice model proteins with Gō potential is studied. A kinetic transition from an exponential behavior to a nonexponential one with a denatured nativeExpand
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