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The utility of sulfonate salts in drug development.
- D. Elder, E. Delaney, F. David
- ChemistryJournal of pharmaceutical sciences
- 1 July 2010
TLDR
An improved HPLC assay for the assessment of liver slice metabolic viability using 7-ethoxycoumarin.
- J. Walsh, J. Patanella, K. Halm, K. Facchine
- Chemistry, BiologyDrug metabolism and disposition: the biological…
- 1 August 1995
TLDR
Available guidance and best practices for conducting force degradation studies
- D. Reynolds, K. Facchine, J. Mullaney, Karen M. Alsante, T. D. Hatajik, M. Motto
- Engineering
- 2002
This article summarizes the collective views of industry participants at a Pharmaceutical Research and Manufacturers of America Analytical Research and Development Steering Committee workshop on…
Separation and identification of retinoic acid photo-isomers
- M. Motto, K. Facchine, M. Cotter
- Chemistry
- 1989
Simultaneous quantitation of trace level hydrazine and acetohydrazide in pharmaceuticals by benzaldehyde derivatization with sample 'matrix matching' followed by liquid chromatography-mass…
- L. Cui, K. Jiang, David Q. Liu, K. Facchine
- ChemistryJournal of chromatography. A
- 2 September 2016
A Detailed Study of Sulfonate Ester Formation and Solvolysis Reaction Rates and Application toward Establishing Sulfonate Ester Control in Pharmaceutical Manufacturing Processes
- A. Teasdale, E. Delaney, F. David
- Biology
- 10 March 2010
TLDR
Mechanism and Processing Parameters Affecting the Formation of Methyl Methanesulfonate from Methanol and Methanesulfonic Acid: An Illustrative Example for Sulfonate Ester Impurity Formation
- A. Teasdale, S. Eyley, F. David
- Chemistry
- 14 January 2009
Sulfonate salts offer useful modification of physicochemical properties of active pharmaceutical ingredients (APIs) containing basic groups, but there are regulatory concerns over the presence of…
Development and validation of an automated static headspace gas chromatography-mass spectrometry (SHS-GC-MS) method for monitoring the formation of ethyl methane sulfonate from ethanol and methane…
- Karine Jacq, E. Delaney, F. David
- ChemistryJournal of pharmaceutical and biomedical analysis
- 15 December 2008
An Approach to Control Strategies for Sulfonate Ester Formation in Pharmaceutical Manufacturing Based on Recent Scientific Understanding
- D. Elder, K. Facchine, A. Teasdale
- Chemistry
- 12 October 2012
The issue of sulfonate ester formation is one that has been of significant concern to regulatory authorities since the start of the millennia. These concerns, focused primarily on the risk of ester…
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