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Neurocognitive endophenotypes of impulsivity and compulsivity: towards dimensional psychiatry
A key criticism of the main diagnostic tool in psychiatry, the Diagnostic and Statistical Manual of Mental Health Disorders (DSM-IV), is that it lacks a biological footing. In this article, we argueExpand
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Hierarchical Modularity in Human Brain Functional Networks
TLDR
We investigate the hierarchical modular (or "modules-within-modules") decomposition of human brain functional networks, measured using functional magnetic resonance imaging in 18 healthy volunteers under no-task or resting conditions. Expand
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Reflection Impulsivity in Current and Former Substance Users
BACKGROUND Chronic drug use is associated with increased impulsivity, risky decision making, and impaired behavioral control, but the underlying mechanisms of this neurocognitive profile remainExpand
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Drug Addiction Endophenotypes: Impulsive Versus Sensation-Seeking Personality Traits
Background Genetic factors have been implicated in the development of substance abuse disorders, but the role of pre-existing vulnerability in addiction is still poorly understood. Personality traitsExpand
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Abnormal structure of frontostriatal brain systems is associated with aspects of impulsivity and compulsivity in cocaine dependence
A growing body of preclinical evidence indicates that addiction to cocaine is associated with neuroadaptive changes in frontostriatal brain systems. Human studies in cocaine-dependent individualsExpand
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A wavelet method for modeling and despiking motion artifacts from resting-state fMRI time series
TLDR
We propose a data-driven, spatially-adaptive, wavelet-based method for identifying, modeling, and removing non-stationary events in fMRI time series, caused by head movement, without the need for data scrubbing. Expand
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Chronic cocaine but not chronic amphetamine use is associated with perseverative responding in humans
RationaleChronic drug use has been associated with increased impulsivity and maladaptive behaviour, but the underlying mechanisms of this impairment remain unclear. We investigated the ability toExpand
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Abnormal Brain Structure Implicated in Stimulant Drug Addiction
Nature or Drug Abuse? There are significant structural changes in striatal and prefrontal brain regions of stimulant drugdependent individuals. However, it is not clear if these brain abnormalitiesExpand
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Abnormal frontal activations related to decision-making in current and former amphetamine and opiate dependent individuals
RationaleThere is converging evidence for impairments in decision-making in chronic substance users. In the light of findings that substance abuse is associated with disruptions of the functioning ofExpand
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Meta-analysis of structural brain abnormalities associated with stimulant drug dependence and neuroimaging of addiction vulnerability and resilience
Since the first study in stimulant-dependent individuals using structural MRI was published fifteen years ago, much evidence has accumulated on brain abnormalities associated with stimulant drugExpand
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