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Up-Regulation of Cyclooxygenase-2 Expression Is Involved in R(+)-Methanandamide-Induced Apoptotic Death of Human Neuroglioma Cells
TLDR
COX-2 is defined as a hitherto unknown target by which a cannabinoid induces apoptotic death of glioma cells and the data show that pharmacological concentrations of celecoxib may interfere with the proapoptotic action of R(+)-MA and anandamide, suggesting that cotreatment with COx-2 inhibitors could diminishglioma regression induced by these compounds. Expand
R(+)-Methanandamide-Induced Apoptosis of Human Cervical Carcinoma Cells Involves A Cyclooxygenase-2-Dependent Pathway
TLDR
This study demonstrates COX-2 induction and synthesis of L-PGDS-derived, PPARγ-activating PGs as a possible mechanism of apoptosis by MA. Expand
R(+)-methanandamide-induced cyclooxygenase-2 expression in H4 human neuroglioma cells: possible involvement of membrane lipid rafts.
TLDR
The results suggest that R(+)-MA induces COX-2 expression in human neuroglioma cells via a pathway linked to lipid raft microdomains, as well as phosphorylation of p38 and p42/44 MAPKs. Expand
Decisive role of cyclooxygenase-2 and lipocalin-type prostaglandin D synthase in chemotherapeutics-induced apoptosis of human cervical carcinoma cells
TLDR
COX-2 induction and synthesis of L-PGDS-derived, PPARγ-activating PGs as a decisive target by which several chemotherapeutics induce apoptosis is suggested, suggesting that COx-2 inhibition during cancer therapy could diminish its efficacy. Expand
Upregulation of tissue inhibitor of matrix metalloproteinases-1 confers the anti-invasive action of cisplatin on human cancer cells
TLDR
A hitherto unknown mechanism by which cisplatin exerts its antimetastatic properties on highly invasive cancer cells is demonstrated, with findings showing a concentration-dependent inhibition of Matrigel invasion by recombinant TIMP-1. Expand
R(+)-Methanandamide Elicits a Cyclooxygenase-2-Dependent Mitochondrial Apoptosis Signaling Pathway in Human Neuroglioma Cells
TLDR
R(+)-MA-induced apoptosis is mediated via a mitochondrial-dependent pathway that becomes activated, at least in part, through up-regulation of the COX-2 enzyme. Expand
Results of the 2012 EMWA salary survey
EMWA members were surveyed in late 2012 and early 2013 about their current salary levels. A total of 320 individuals responded. Most were women, between 31 and 50 years of age, and native speakers ofExpand