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Hypertriglyceridemia as a cardiovascular risk factor.
TLDR
Three recent prospective epidemiologic studies have shown that plasma triglyceride and low-density lipoprotein particle size predict subsequent coronary artery disease in Caucasian populations, demonstrating the importance of triglyceride levels as a risk factor for cardiovascular disease.
Aristolochic acid-associated urothelial cancer in Taiwan
TLDR
It is concluded that exposure to aristolochic acid contributes significantly to the incidence of UUC in Taiwan, a finding with significant implications for global public health.
Effect of genotype on phenotype and mortality in cystic fibrosis: a retrospective cohort study
TLDR
Patients with cystic fibrosis have distinct genetic subgroups that are associated with mild clinical manifestations and low mortality, and differences in phenotype are also related to the functional classification of CFTR genotype.
Family history of diabetes as a potential public health tool.
TLDR
Overall, a family history approach appears to be a promising new public health tool to fight the growing epidemic of diabetes in the United States.
Cardiovascular disease mortality in familial forms of hypertriglyceridemia: A 20-year prospective study.
TLDR
Baseline triglyceride level predicted subsequent CVD mortality among relatives in FHTG families, adding to the growing evidence for the importance of hypertriglyceridemia as a risk factor for CVD.
APOE ε4 increases risk for dementia in pure synucleinopathies.
TLDR
The elevated ϵ4 frequency in the pDLB and PDD groups, in which the overall brain neuritic plaque burden was low, indicates that apoE might contribute to neurodegeneration through mechanisms unrelated to amyloid processing.
Aristolactam-DNA adducts are a biomarker of environmental exposure to aristolochic acid.
TLDR
Dietary exposure to aristolochic acid is causally related to endemic nephropathy and carcinomas of the upper urinary tract and TP53 mutations in tumor tissues are identified by chip sequencing.
Association analysis of MAPT H1 haplotype and subhaplotypes in Parkinson's disease
TLDR
An inversion polymorphism of approximately 900kb on chromosome 17q21, which includes the microtubule‐associated protein tau (MAPT) gene defines two haplotype clades, H1 and H2, which are observed to have a marginally significant excess among patients with Parkinson's disease.
SNCA variant associated with Parkinson disease and plasma alpha-synuclein level.
TLDR
The data suggest that 1 or more unidentified functional SNCA variants modify risk for PD and that the effect is larger than and independent of REP1.
LRRK2 G2019S in families with Parkinson disease who originated from Europe and the Middle East: evidence of two distinct founding events beginning two millennia ago.
TLDR
The data suggest two separate founding events for G2019S in these populations, beginning at a time that coincides with the Jewish Diasporas.
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