• Publications
  • Influence
Definition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO).
TLDR
A survey and conference was conducted and a controversies conference was sponsored to provide a clear understanding to both the nephrology and nonnephrology communities of the evidence base for the definition and classification recommended by Kidney Disease Quality Outcome Initiative (K/DOQI).
The definition, classification, and prognosis of chronic kidney disease: a KDIGO Controversies Conference report.
TLDR
KDIGO has convened a workgroup to develop a global clinical practice guideline for the definition, classification, and prognosis of chronic kidney disease.
Normalization of hemoglobin level in patients with chronic kidney disease and anemia.
TLDR
In patients with chronic kidney disease, early complete correction of anemia does not reduce the risk of cardiovascular events and there was no significant difference in the combined incidence of adverse events between the two groups.
Chronic kidney disease as a global public health problem: approaches and initiatives - a position statement from Kidney Disease Improving Global Outcomes.
TLDR
The 2006 KDIGO Controversies Conference on CKD was convened to consider six major topics: CKD classification, CKD screening and surveillance, public policy for CKD, CVD and CVD risk factors as risk factors for development and progression of CKd, association of CKD with chronic infections, and (6) association of CJD with cancer.
Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition.
TLDR
Clinical and genetic evidence is provided that activation of HIF-1 signaling in renal epithelial cells is associated with the development of chronic renal disease and may promote fibrogenesis by increasing expression of extracellular matrix-modifying factors and lysyl oxidase genes and by facilitating EMT.
A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease.
TLDR
The use of darbepoetin alfa in patients with diabetes, chronic kidney disease, and moderate anemia who were not undergoing dialysis did not reduce the risk of either of the two primary composite outcomes (either death or a cardiovascular event ordeath or a renal event) and was associated with an increased risk of stroke.
Oxidative stress in end-stage renal disease: an emerging threat to patient outcome.
TLDR
It is important to consider oxidative stress as a potentially important source of patient morbidity and mortality, although this knowledge is not yet immediately applicable in the clinical arena.
Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C–dependent buffering mechanism
TLDR
It is shown that a high-salt diet in rats leads to interstitial hypertonic Na+ accumulation in skin, resulting in increased density and hyperplasia of the lymphcapillary network and VEGFC is identified as an osmosensitive, hypertonicity-driven gene intimately involved in salt-induced hypertension.
Rate of erythropoietin formation in humans in response to acute hypobaric hypoxia.
TLDR
EPO levels during hypoxia were significantly elevated after 114 and 84 min (3,000 and 4,000 m) and rising thereafter continuously for the period investigated, corresponding to 1.8-fold and 3.0-fold increases in the calculated production rate of the hormone.
...
1
2
3
4
5
...