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Brain oxytocin inhibits the (re)activity of the hypothalamo–pituitary–adrenal axis in male rats: involvement of hypothalamic and limbic brain regions

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The role of substance P in stress and anxiety responses

It was hypothesised that blockade of NK1 receptors may attenuate stress responses and exert anxiolytic-like effects and preclinical and clinical studies have found evidence in favour of such an assumption.
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Alterations in Central Neuropeptide Expression, Release, and Receptor Binding in Rats Bred for High Anxiety: Critical Role of Vasopressin

The elevated expression and release of AVP within the PVN of HAB rats together with the behavioral effects of the AVP V1-receptor antagonist suggest a critical involvement of this neuropeptide in neuroendocrine and behavioral phenomena associated with trait anxiety/depression.
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Substance P in the medial amygdala: Emotional stress-sensitive release and modulation of anxiety-related behavior in rats

The MeA is identified as a critical brain area for the involvement of SP transmission in anxiety responses and as a putative site of action for the recently discovered therapeutic effects of SP antagonists in the treatment of stress-related disorders.
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Release of Oxytocin in the Rat Central Amygdala Modulates Stress-Coping Behavior and the Release of Excitatory Amino Acids

Findings demonstrate a significant activation of the oxytocinergic system in the CeA in response to swim stress and indicate that OXT receptor-mediated mechanisms within the amygdala are involved in the generation of passive stress-coping strategies, which might be mediated at least in part via its inhibitory influence on the local release of excitatory amino acids during stress.
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Tachykinin receptors as therapeutic targets in stress-related disorders.

Evidence derived from anatomical, neurochemical, pharmacological and behavioral studies demonstrating the localization of tachykinin neuropeptides in brain areas known to be implicated in stress-mechanisms, mood/anxiety regulation and emotion-processing is summarized.
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Acute transcranial magnetic stimulation of frontal brain regions selectively modulates the release of vasopressin, biogenic amines and amino acids in the rat brain

These data provide the first in vivo evidence that acute rTMS of frontal brain regions has a differentiated modulatory effect on selected neurotransmitter/neuromodulator systems in distinct brain areas.
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Neurokinin 1 receptor antagonism promotes active stress coping via enhanced septal 5-HT transmission

It is found that exposure to forced swim stress increased SP release in the rat lateral septum (LS), a key area in processing emotions and stress responses, and that NK1R blockade can elicit a functionally significant facilitatory effect on 5-HT transmission.
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Induction of ΔFosB in the Periaqueductal Gray by Stress Promotes Active Coping Responses

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Forced swimming triggers vasopressin release within the amygdala to modulate stress‐coping strategies in rats

The results of the present study suggest that AVP is released within septum and amygdala to balance the behavioural response during forced swimming.
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