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Peripheral benzodiazepine receptor in cholesterol transport and steroidogenesis
PBR is an indispensable element of the steroidogenic machinery and its presence is vital for hCG-induced steroidogenesis by Leydig cells. Expand
Ginkgo biloba extract (EGb 761) and CNS functions: basic studies and clinical applications.
EGb 761 possesses antioxidant and free radical-scavenging activities, it reverses age-related losses in brain alpha 1-adrenergic, 5-HT1A and muscarinic receptors, protects against ischaemic neuronal death, preserves the function of the hippocampal mossy fiber system, increases hippocampal high-affinity choline uptake, and opposes the detrimental effects of ischaemia. Expand
Neuroprotective effects of bilobalide, a component of the Ginkgo biloba extract (EGb 761), in gerbil global brain ischemia
Oral administration of bilobalide and EGb 761 protect against ischemia-induced neuron death and reductions in mitochondrial gene expression, which are suggested to be important for neuroprotective effects against ischemic injury. Expand
Ginkgo biloba extracts and cancer: a research area in its infancy
Recent studies conducted with various molecular, cellular and whole animal models have revealed that leaf extracts of Ginkgo biloba may have anticancer (chemopreventive) properties that are relatedExpand
Cardioprotective and anti-oxidant effects of the terpenoid constituents of Ginkgo biloba extract (EGb 761).
Cardioprotective effects of therapeutically relevant doses of Ginkgo biloba extract and its terpenoid constituents appear to involve an inhibition of free radical formation rather than direct free radical scavenging. Expand
Peripheral-Type Benzodiazepine Receptor
Comprehension of the molecular systems underlying the control of steroid hormone biosynthesis is essential for the study and treatment of a multitude of physiological disorders. Expand
Protection of hypoxia-induced ATP decrease in endothelial cells by ginkgo biloba extract and bilobalide.
Due to their localization at the interface between blood and tissue, endothelial cells are the first target of any change occurring within the blood, and alterations of their functions can seriouslyExpand
[Pharmacokinetic properties of Bilobalide and Ginkgolides A and B in healthy subjects after intravenous and oral administration of Ginkgo biloba extract (EGb 761)].
The pharmacokinetics of GinkGolide A, Ginkgolide B and Bilobalide, which are compounds extracted from the dried leaves of the Ginkgo biloba tree, were investigated in 12 young healthy volunteers after single-dose administration of Ginkinggo Biloba extract. Expand
Ginkgo biloba Extracts EGb 761 and Bilobalide Increase NADH Dehydrogenase mRNA Level and Mitochondrial Respiratory Control Ratio in PC12 Cells
Results provide evidence that EGb 761 and bilobalide exert their protective effects by up-regulating mitochondrial ND1 gene expression and by decreasing state 4 respiration, whose increase is thought to be responsible for oxidative damage. Expand
Effects of single intraperitoneal injections of an extract of Ginkgo biloba (EGb 761) and its terpene trilactone constituents on barbital-induced narcosis in the mouse.
It is hypothesized that interactions with the picrotoxinin/TBPT site of GABA-regulated Cl- channels of the CNS may be involved and this information appears useful in explaining the clinically observed "vigilance-enhancing" and "antidepressant-like" actions of EGb 761. Expand