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Defective mammopoiesis, but normal hematopoiesis, in mice with a targeted disruption of the prolactin gene
Prolactin (PRL) has been implicated in numerous physiological and developmental processes. The mouse PRL gene was disrupted by homologous recombination. The mutation caused infertility in femaleExpand
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Age-related changes in lymphocyte development and function
The effects of aging on the immune system are widespread and extend from hematopoietic stem cells and lymphoid progenitors in the bone marrow and thymus to mature lymphocytes in secondary lymphoidExpand
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Identification of a B-1 B cell–specified progenitor
The B-1 subpopulation of B lymphocytes differs phenotypically and functionally from conventional B-2 B cells. B-1 B cells are proposed to derive from a distinct progenitor, but such a population hasExpand
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Regulation of hemopoiesis by bone marrow stromal cells and their products.
  • K. Dorshkind
  • Biology, Medicine
  • Annual review of immunology
  • 1990
Hemopoietic precursors can be identified in a number of tissues, but the bone marrow is the only site in normal adult mammals in which myelopoiesis, erythropoiesis, and lymphopoiesis proceedExpand
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Causes, consequences, and reversal of immune system aging.
The effects of aging on the immune system are manifest at multiple levels that include reduced production of B and T cells in bone marrow and thymus and diminished function of mature lymphocytes inExpand
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The protean nature of cells in the B lymphocyte lineage.
The subdivision of bone marrow (BM) with surface markers and reporter systems and the use of multiple culture and transplantation assays to assess differentiation potential have led to extraordinaryExpand
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Reduction in the Developmental Potential of Intrathymic T Cell Progenitors with Age1
Current models of thymic involution propose that intrinsic developmental defects in intrathymic T cell precursors do not contribute to age-related declines in thymopoiesis. This premise wasExpand
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A stromal cell line from myeloid long-term bone marrow cultures can support myelopoiesis and B lymphopoiesis.
The production of B lymphocytes and myeloid cells occurs in the bone marrow in association with a supporting population of stromal cells. To determine whether these processes are dependent upon theExpand
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B-1 B cell development in the fetus and adult.
Models of hematopoiesis often depict lymphocyte production as a uniform process in which a homogenous population of hematopoietic stem cells (HSCs) generates progenitors from which all types ofExpand
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Myonuclear apoptosis in dystrophic mdx muscle occurs by perforin-mediated cytotoxicity.
Myonuclear apoptosis is an early event in the pathology of dystrophin-deficient muscular dystrophy in the mdx mouse. However, events that initiate apoptosis in muscular dystrophy are unknown, andExpand
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