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Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy
TLDR
The working group report presents a broad data gathering strategy applicable to this early stage in the development of a risk assessment process for nanomaterials, and there is a strong likelihood that biological activity of nanoparticles will depend on physicochemical parameters not routinely considered in toxicity screening studies.
Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study.
TLDR
Exposing the mesothelial lining of the body cavity of mice to long multiwalled carbon nanotubes results in asbestos-like, length-dependent, pathogenic behaviour, including inflammation and the formation of lesions known as granulomas.
The potential risks of nanomaterials: a review carried out for ECETOC
TLDR
This review shows that only few specific nanoparticles have been investigated in a limited number of test systems and extrapolation of this data to other materials is not possible, and limited ecotoxicological data for nanomaterials precludes a systematic assessment of the impact of Nanoparticles on ecosystems.
Carbon nanotubes: a review of their properties in relation to pulmonary toxicology and workplace safety.
TLDR
The toxicological paradigms applicable to the toxicity of inhaled CNT are set out, building on the toxicological database on nanoparticles (NP) and fibers, and the current paradigm for fiber toxicology is discussed.
Diesel Exhaust Inhalation Causes Vascular Dysfunction and Impaired Endogenous Fibrinolysis
TLDR
At levels encountered in an urban environment, inhalation of dilute diesel exhaust impairs 2 important and complementary aspects of vascular function in humans: the regulation of vascular tone and endogenous fibrinolysis.
Asbestos, carbon nanotubes and the pleural mesothelium: a review of the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma
TLDR
This review seeks to synthesise new data with multi-walled carbon nanotubes (CNT) with that hypothesis for the behaviour of long fibres in the lung and their retention in the parietal pleura leading to the initiation of inflammation and pleural pathology such as mesothelioma.
Combustion-derived nanoparticles: A review of their toxicology following inhalation exposure
TLDR
CDNP can be seen as a group of particulate toxins unified by a common mechanism of injury and properties of translocation which have the potential to mediate a range of adverse effects in the lungs and other organs and warrant further research.
Toxicology of nanoparticles: A historical perspective
TLDR
This article aims to cover hazards relevant to humans, provides an introduction to some of the newly emerging literature on fate and behavior of NP in the environment, as well as describing their ecotoxicology in a variety of species.
Ischemic and thrombotic effects of dilute diesel-exhaust inhalation in men with coronary heart disease.
TLDR
Brief exposure to dilute diesel exhaust promotes myocardial ischemia and inhibits endogenous fibrinolytic capacity in men with stable coronary heart disease and points to ischemic and thrombotic mechanisms that may explain in part the observation that exposure to combustion-derived air pollution is associated with adverse cardiovascular events.
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