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- K. Donaldson, V. Stone, A. Clouter, L. Renwick, W. MacNee
- Occupational and environmental medicine
- 1 March 2001
There is a long history of disease caused by inhaled particles that stretches from Agricola and Paracelsus in the 14th century up to the present. In this century the twin scourges of asbestos and… Expand
Calcium and ROS-mediated activation of transcription factors and TNF-alpha cytokine gene expression in macrophages exposed to ultrafine particles.
- D. Brown, K. Donaldson, +5 authors V. Stone
- Biology, Chemistry
- American journal of physiology. Lung cellular and…
- 10 October 2003
Ultrafine (Uf) particles are a component of particulate air pollution suggested to be responsible for the health effects associated with elevations of this pollutant. We have previously suggested… Expand
Inhalation of poorly soluble particles. II. Influence Of particle surface area on inflammation and clearance.
- C. Tran, Diane Buchanan, R. Cullen, A. Searl, A. D. Jones, K. Donaldson
- Chemistry, Medicine
- Inhalation toxicology
In this article the volumetric overload hypothesis, which predicts the impairment of clearance of particles deposited in the lung in terms of particle volume, is reevaluated. The degree to which… Expand
Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs.
- J. Marwick, P. Kirkham, +6 authors I. Rahman
- Biology, Medicine
- American journal of respiratory cell and…
- 27 August 2004
Cigarette smoke-triggered inflammation is considered to play a central role in the development of chronic obstructive pulmonary disease by a mechanism that may involve enhanced proinflammatory gene… Expand
Hazard and risk assessment of a nanoparticulate cerium oxide-based diesel fuel additive - a case study.
Envirox is a scientifically and commercially proven diesel fuel combustion catalyst based on nanoparticulate cerium oxide and has been demonstrated to reduce fuel consumption, greenhouse gas… Expand
The effect of smoking on the transcriptional regulation of lung inflammation in patients with chronic obstructive pulmonary disease.
- Patryk Szulakowski, Ann J L Crowther, +5 authors E. M. Drost
- American journal of respiratory and critical care…
- 1 July 2006
RATIONALE Chronic obstructive pulmonary disease (COPD) is believed to result from an abnormal inflammatory response in the lungs to noxious particles and gases usually found in cigarette smoke. … Expand
The pathogenicity of long versus short fibre samples of amosite asbestos administered to rats by inhalation and intraperitoneal injection.
- J. M. Davis, J. Addison, R. Bolton, K. Donaldson, A. D. Jones, T. Smith
- British journal of experimental pathology
- 1 June 1986
For many years it has been accepted that fibre dimensions are the most important factor in the development of asbestos related disease with long fibres being more dangerous than short for all types… Expand
Diesel exhaust inhalation increases thrombus formation in man.
AIMS Although the mechanism is unclear, exposure to traffic-derived air pollution is a trigger for acute myocardial infarction (MI). The aim of this study is to investigate the effect of diesel… Expand
The quartz hazard: a variable entity.
An IARC Working Group recently classified crystalline silica (quartz) into IARC's Group 1, i.e. a carcinogen. This classification is based on evidence of carcinogenicity in experimental animals and… Expand
Differences in the extent of inflammation caused by intratracheal exposure to three ultrafine metals: role of free radicals.
- Q. Zhang, Y. Kusaka, K. Sato, K. Nakakuki, N. Kohyama, K. Donaldson
- Medicine, Chemistry
- Journal of toxicology and environmental health…
- 27 March 1998
Nickel and cobalt, which belong to the same elemental group, are known to cause interstitial lung disease and bronchial asthma. The ability of these metals to injure lung cells and cause inflammation… Expand