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Therapeutic effect of adriamycin encapsulated in long‐circulating liposomes on meth‐a‐sarcoma‐bearing mice
Long‐circulating liposomes modified with a uronic‐acid derivative, palmityl‐D‐glucuronide (PGIcUA), have been developed previously for the passive targeting of liposomes to tumor tissues. In this… Expand
Antitumor activity of vincristine encapsulated in glucuronide-modified long-circulating liposomes in mice bearing Meth A sarcoma.
- Y. Tokudome, N. Oku, K. Doi, Y. Namba, S. Okada
- Chemistry, Medicine
- Biochimica et biophysica acta
- 21 February 1996
Liposomes modified with the uronic acid derivative palmityl-D-glucuronide (PGlcUA) have a long circulation time and tend to accumulate in the tumors of tumor-bearing mice. Taking advantage of this… Expand
Therapeutic effect of reticuloendothelial system (RES)-avoiding liposomes containing a phospholipid analogue of 5-fluorouracil, dipalmitoylphosphatidylfluorouridine, in Meth A sarcoma-bearing mice.
Reticuloendothelial system (RES)-avoiding liposomes are known to accumulate in tumor tissues due to passive targeting. Dipalmitoylphosphatidylfluorouridine (DPPF), a potent antitumor agent readily… Expand
Potential usage of thermosensitive liposomes for macromolecule delivery.
Since transient swelling during phase transition of liposomes with hyper-osmotic internal aqueous phase may cause permeation of large molecules through the lipid bilayer, this type of liposomes can… Expand
Therapeutic efficacy of 5-fluorouracil prodrugs using endogenous serum proteins as drug carriers: a new strategy in drug delivery system.
To establish a novel drug delivery system for 5-fluorouracil (5FU), we have developed a system in which the low-molecular-weight prodrugs of 5FU bound to endogenous serum proteins, thus circulating… Expand
Application of thermosensitive liposomes for macromolecule delivery.
It is useful if the bioactive macromolecules, such as cytokines, could be delivered to the desired site. Liposomes have been used successfully as carriers for various agents. Targeting of liposomes… Expand
Application of RES-avoiding liposomes encapsulated adriamycin for cancer therapy.
Reticuloendothelial system (RES)-avoiding liposomes having long circulating character have been expected for a useful drug carrier especially for a carrier of anticancer agents, since they tend to… Expand