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Dominant forces in protein folding.
  • K. Dill
  • Chemistry, Medicine
  • Biochemistry
  • 7 August 1990
T e purpose of this review is to assess the nature and magnitudes of the dominant forces in protein folding. Since proteins are only marginally stable at room temperature,’ no type of molecularExpand
  • 3,107
  • 61
  • PDF
From Levinthal to pathways to funnels
While the classical view of protein folding kinetics relies on phenomenological models, and regards folding intermediates in a structural way, the new view emphasizes the ensemble nature of proteinExpand
  • 2,072
  • 56
Theory for the folding and stability of globular proteins.
  • K. Dill
  • Chemistry, Medicine
  • Biochemistry
  • 12 March 1985
Using lattice statistical mechanics, we develop theory to account for the folding of a heteropolymer molecule such as a protein to the globular and soluble state. Folding is assumed to be driven byExpand
  • 1,110
  • 42
A lattice statistical mechanics model of the conformational and sequence spaces of proteins
We develop theory to explore the relationship between the amino acid sequence of a protein and its native structure. A protein is modeled as a specific sequence of H (nonpolar) and P (polar)Expand
  • 833
  • 34
The Protein Folding Problem
Thousands of different types of proteins occur in biological organisms. They are responsible for catalyzing and regulating biochemical reactions, transporting molecules, the chemistry of vision andExpand
  • 476
  • 22
Statistical potentials extracted from protein structures: how accurate are they?
"Statistical potentials" are energies widely used in computer algorithms to fold, dock, or recognize protein structures. They are derived from: (1) observed pairing frequencies of the 20 amino acidsExpand
  • 397
  • 16
  • PDF
The Protein-Folding Problem, 50 Years On
Protein Folding: Past and Future Fifty years ago the Nobel Prize in chemistry was awarded to Max Perutz and John Kendrew for determining the structure of globular proteins. Since first viewing theirExpand
  • 895
  • 15
  • PDF
Small molecule hydration free energies in explicit solvent: An extensive test of fixed-charge atomistic simulations.
Using molecular dynamics free energy simulations with TIP3P explicit solvent, we compute the hydration free energies of 504 neutral small organic molecules and compare them to experiments. We find,Expand
  • 265
  • 15
Cooperativity in protein-folding kinetics.
How does a protein find its native state without a globally exhaustive search? We propose the "HZ" (hydrophobic zipper) hypothesis: hydrophobic contacts act as constraints that bring other contactsExpand
  • 420
  • 14
  • PDF
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