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The A622 gene in Nicotiana glauca (tree tobacco): evidence for a functional role in pyridine alkaloid synthesis
Nicotiana glauca (Argentinean tree tobacco) is atypical within the genus Nicotiana, accumulating predominantly anabasine rather than nicotine and/or nornicotine as the main component of its leafExpand
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RNAi-mediated down-regulation of ornithine decarboxylase (ODC) leads to reduced nicotine and increased anatabine levels in transgenic Nicotiana tabacum L.
In leaf and root tissues of Nicotiana tabacum L. (common tobacco), nicotine is by far the predominant pyridine alkaloid, with anatabine representing only a minor component of the total alkaloidExpand
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An Interspecific Nicotiana Hybrid as a Useful and Cost-Effective Platform for Production of Animal Vaccines
The use of transgenic plants to produce novel products has great biotechnological potential as the relatively inexpensive inputs of light, water, and nutrients are utilised in return for potentiallyExpand
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Structure and expression of the quinolinate phosphoribosyltransferase (QPT) gene family in Nicotiana.
Synthesis of wound-inducible pyridine alkaloids is characteristic of species in the genus Nicotiana. The enzyme quinolinate phosphoribosyltransferase (QPT) plays a key role in facilitating theExpand
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LRGUK-1 Is Required for Basal Body and Manchette Function during Spermatogenesis and Male Fertility
Male infertility affects at least 5% of reproductive age males. The most common pathology is a complex presentation of decreased sperm output and abnormal sperm shape and motility referred to asExpand
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Loss of GGN Leads to Pre-Implantation Embryonic Lethality and Compromised Male Meiotic DNA Double Strand Break Repair in the Mouse
The integrity of male germ cell genome is critical for the correct progression of spermatogenesis, successful fertilization, and proper development of the offspring. Several DNA repair pathways existExpand
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Effects of down-regulating ornithine decarboxylase upon putrescine-associated metabolism and growth in Nicotiana tabacum L.
Highlight RNAi-mediated reduction of ornithine decarboxylase gene activity in tobacco has negative effects on plant growth and leads to widespread alterations in primary and secondary metabolism,Expand
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Copy number variation associated with meiotic arrest in idiopathic male infertility.
OBJECTIVE To assess the association between copy number variations (CNVs) and meiotic arrest and azoospermic men. DESIGN Genetic association study. SETTING University. PATIENT(S) AustralianExpand
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RNAi-mediated down-regulation of ornithine decarboxylase (ODC) impedes wound-stress stimulation of anabasine synthesis in Nicotiana glauca.
Unlike most Nicotiana species, leaf tissues of the globally significant weed Nicotiana glauca Grah. (Argentinian tree tobacco) contains anabasine as the main component of its alkaloid pool, withExpand
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LRGUK1 is part of a multiprotein complex required for manchette function and male fertility
Infertility occurs in 1 in 20 young men and is idiopathic in origin in most. We have reported that the leucine‐rich repeat (LRR) and guanylate kinase‐like domain containing, isoform (LRGUK)‐1 isExpand
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