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Functional profiling of the Saccharomyces cerevisiae genome
Determining the effect of gene deletion is a fundamental approach to understanding gene function. Conventional genetic screens exhibit biases, and genes contributing to a phenotype are often missed.Expand
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A multimodal cortical network for the detection of changes in the sensory environment
Sensory stimuli undergoing sudden changes draw attention and preferentially enter our awareness. We used event-related functional magnetic-resonance imaging (fMRI) to identify brain regionsExpand
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Pain-related neurons in the human cingulate cortex
Although it is widely accepted that the cortex participates in pain perception, there is no direct evidence for the existence of cortical neurons that respond to noxious or painful stimuli in humans.Expand
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Functional MRI study of thalamic and cortical activations evoked by cutaneous heat, cold, and tactile stimuli.
Positron emission tomography studies have provided evidence for the involvement of the thalamus and cortex in pain and temperature perception. However, the involvement of these structures in pain andExpand
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Two systems of resting state connectivity between the insula and cingulate cortex
The insula and cingulate cortices are implicated in emotional, homeostatic/allostatic, sensorimotor, and cognitive functions. Non‐human primates have specific anatomical connections betweenExpand
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A neurocognitive model of attention to pain: Behavioral and neuroimaging evidence
READ – Unite de Readaptation et de Medecine physique, Universite catholique de Louvain, Louvain-la-Neuve & Brussels, 1200 Brussels, Belgium Department of Experimental-Clinical and Health Psychology,Expand
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An fMRI study of the anterior cingulate cortex and surrounding medial wall activations evoked by noxious cutaneous heat and cold stimuli
&NA; The anterior cingulate cortex (ACC) and adjacent regions in the medial wall have been implicated in sensory, motor and cognitive processes, including pain. Our previous functional magneticExpand
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Theories of pain: from specificity to gate control.
Several theoretical frameworks have been proposed to explain the physiological basis of pain, although none yet completely accounts for all aspects of pain perception. Here, we provide a historicalExpand
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Systemic alpha-adrenergic blockade with phentolamine: a diagnostic test for sympathetically maintained pain.
The diagnosis of sympathetically maintained pain (SMP) is typically established by assessment of pain relief during local anesthetic blockade of the sympathetic ganglia that innervate the painfulExpand
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