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Free triiodothyronine has a distinct circadian rhythm that is delayed but parallels thyrotropin levels.
CONTEXT TSH is known to have a circadian rhythm, but the relationship between this and any rhythm in T(4) and T(3) has not been clearly demonstrated. OBJECTIVE With a view to optimizing thyroidExpand
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Radiation-induced hypopituitarism after cancer therapy: who, how and when to test
  • K. Darzy
  • Medicine
  • Nature Clinical Practice Endocrinology…
  • 1 February 2009
Subtle to frank abnormalities in hypothalamic–pituitary axis function are frequently seen in cancer survivors who have received prophylactic or therapeutic cranial irradiation. The growth hormoneExpand
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Hypopituitarism following radiotherapy
Deficiencies in anterior pituitary hormones secretion ranging from subtle to complete occur following radiation damage to the hypothalamic–pituitary (h–p) axis, the severity and frequency of whichExpand
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Circadian and stimulated thyrotropin secretion in cranially irradiated adult cancer survivors.
  • K. Darzy, S. Shalet
  • Medicine
  • The Journal of clinical endocrinology and…
  • 1 December 2005
CONTEXT It has been claimed that with the use of the TRH test and knowledge of the nocturnal TSH surge, the diagnosis of so-called hidden central hypothyroidism might be uncovered in a substantialExpand
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The usefulness of the combined growth hormone (GH)-releasing hormone and arginine stimulation test in the diagnosis of radiation-induced GH deficiency is dependent on the post-irradiation time
The diagnostic usefulness of the insulin tolerance test (ITT) in patients with radiation-induced GH deficiency (GHD) is well established, whereas that of the combined GHRH plus arginine stimulationExpand
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Hypopituitarism following Radiotherapy Revisited.
Neuroendocrine disturbances in anterior pituitary hormone secretion are common following radiation damage to the hypothalamic-pituitary (H-P) axis, the severity and frequency of which correlate withExpand
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Hypopituitarism As a Consequence of Brain Tumours and Radiotherapy
Radiation-induced damage to the hypothalamic-pituitary (h-p) axis is associated with a wide spectrum of subtle and frank abnormalities in anterior pituitary hormones secretion. The frequency,Expand
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Pathophysiology of radiation-induced growth hormone deficiency: efficacy and safety of GH replacement.
  • K. Darzy, S. Shalet
  • Medicine
  • Growth hormone & IGF research : official journal…
  • 1 July 2006
Radiation-induced growth hormone deficiency (GHD) is primarily due to hypothalamic damage. GH secretion by the pituitary may be affected either secondary to some degree of quantitative deprivation ofExpand
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GH-deficient survivors of childhood cancer: GH replacement during adult life.
Childhood survivors of cancer are prone to a number of adverse sequelae related to the therapeutic interventions undertaken to achieve remission. The endocrine system is frequently affected;Expand
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Modified-release hydrocortisone to provide circadian cortisol profiles.
CONTEXT Cortisol has a distinct circadian rhythm regulated by the brain's central pacemaker. Loss of this rhythm is associated with metabolic abnormalities, fatigue, and poor quality of life.Expand
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