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The hypothermic effect of late evening melatonin does not block the phase delay induced by concurrent bright light in human subjects
TLDR
The phase delay of the circadian system by evening light appears to be independent of an immediate hyperthermic effect and is not mediated by melatonin. Expand
Evening administration of melatonin and bright light: Interactions on the EEG during sleep and wakefulness
TLDR
Although acute bright light and melatonin administration affected subjective sleepiness, internal sleep structure and EEG power density during sleep and wakefulness in a additive manner, the phase shifting effect of a single evening bright light exposure could not be blocked by exogenous melatonin. Expand
Is Sleep per se a Zeitgeber in Humans?
TLDR
Sleep per se may feed back onto the circadian pacemaker, but it appears to be a weak zeitgeber in humans. Expand
Melatonin Treatment of Winter Depression Following Total Sleep Deprivation: Waking EEG and Mood Correlates
TLDR
Overall, patients with winter depression manifest similar wake EEG characteristics as long sleepers or late chronotype with respect to an insufficient build-up of homeostaticSleep pressure was an effective antidepressant treatment for some patients, but evening melatonin was not more efficacious than placebo in sustaining this antidepressant effect. Expand
Effects of the Seasons and of Bright Light Administered at Different Times of Day on Sleep EEG and Mood in Patients with Seasonal Affective Disorder
TLDR
The reduced amounts of slow wave sleep in the depressive state predicted higher reduction and low posttreatment scores on psychiatric scales and the total amounts and percentage ofslow wave sleep were significantly lower in responders to light compared to both nonresponders and controls. Expand
The Physiological Period Length of the Human Circadian Clock In Vivo Is Directly Proportional to Period in Human Fibroblasts
TLDR
The period of human circadian behaviour is mostly driven by cellular clock properties in normal individuals and can be approximated by measurement in peripheral cells such as fibroblasts, which suggests that period can be modified by prolonged unusual conditions such as the total light deprivation of blindness. Expand
Bright Light for Weight Loss: Results of a Controlled Crossover Trial
TLDR
Morning bright light treatment reduces body fat and appetite in overweight women and may be included in weight control programs. Expand
Impact of oral melatonin on the electroretinogram cone response
TLDR
The impact of melatonin on retinal function should be taken into consideration when used without supervision in chronic self-medication for sleep or circadian disorder treatment, as melatonin appears to reduce input to retinal cones when administered at a time of day when it is not usually present. Expand
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