TOS9 Regulates White-Opaque Switching in Candidaalbicans
- T. Srikantha, A. Borneman, D. Soll
- BiologyEukaryotic Cell
- 1 September 2006
A model was developed for the regulation of spontaneous switching between the opaque state and the white state that includes stochastic changes of Tos9p levels above and below a threshold that induce changes in the chromatin state of an as-yet-unidentified switching locus.
EFG1 Null Mutants of Candida albicansSwitch but Cannot Express the Complete Phenotype of White-Phase Budding Cells
- T. Srikantha, Luong K. Tsai, K. Daniels, D. Soll
- BiologyJournal of Bacteriology
- 15 March 2000
Results demonstrate that EFG1 expression is not essential for the switch event per se, but is essential for a subset of phenotypic characteristics necessary for the full expression of the phenotype of white-phase cells.
N-Acetylglucosamine Induces White to Opaque Switching, a Mating Prerequisite in Candida albicans
- Guanghua Huang, S. Yi, Nidhi Sahni, K. Daniels, T. Srikantha, D. Soll
- BiologyPLoS Pathogens
- 1 March 2010
It is demonstrated that a second signal, N-acetylglucosamine (GlcNAc), a monosaccharide produced primarily by gastrointestinal tract bacteria, also serves as a potent inducer of white to opaque switching and functions primarily through the Ras1/cAMP pathway and phosphorylated Wor1, the gene product of the master switch locus.
α-Pheromone-Induced “Shmooing” and Gene Regulation Require White-Opaque Switching during Candida albicans Mating
- S. Lockhart, Rui Zhao, K. Daniels, D. Soll
- BiologyEukaryotic Cell
- 1 October 2003
It is demonstrated that α-pheromone causes shmooing, the initial step in the mating process, only in a/a cells expressing the opaque phenotype and only at temperatures below that in the human host.
Cell Biology of Mating in Candida albicans
- S. Lockhart, K. Daniels, Rui Zhao, D. Wessels, D. Soll
- BiologyEukaryotic Cell
- 1 February 2003
This study provides the first description of the cell biology of the mating process of C. albicans, suggesting that mating takes place in the absence of karyogamy between naturally occurring, homozygous a and α strains.
Opaque cells signal white cells to form biofilms in Candida albicans
- K. Daniels, T. Srikantha, S. Lockhart, C. Pujol, D. Soll
- BiologyEMBO Journal
- 17 May 2006
It is demonstrated that pheromone induces cohesiveness between white cells, minority opaque cells increase two‐fold the thickness of majority white cell biofilms, and majoritywhite cell biofilmms facilitate minority opaque cell chemotropism.
In Candida albicans, white-opaque switchers are homozygous for mating type.
- S. Lockhart, C. Pujol, D. Soll
- Biology, MedicineGenetics
- 1 October 2002
The results demonstrate that mating-competent strains of C. albicans exist naturally in patient populations and suggest that mating may play a role in the genesis of diversity in this pernicious fungal pathogen.
The Histone Deacetylase Genes HDA1 andRPD3 Play Distinct Roles in Regulation of High-Frequency Phenotypic Switching in Candida albicans
- T. Srikantha, L. Tsai, K. Daniels, A. Klar, D. Soll
- BiologyJournal of Bacteriology
- 1 August 2001
The two deacetylase genes HDA1 and RPD3 play distinct roles in the suppression of switching, that the two play distinct and selective role in the regulation of phase-specific genes, and that the deacetyases are in turn regulated by switching.
The two-component hybrid kinase regulator CaNIK1 of Candida albicans.
- T. Srikantha, L. Tsai, K. Daniels, L. Enger, K. Highley, D. Soll
- BiologyMicrobiology
- 1 October 1998
Partial deletion of both CaNIK1 alleles did not inhibit either high-frequency phenotypic switching or the bud-hypha transition in high salt concentrations, but in both cases the efficiency of the developmental process was reduced.
Skin Facilitates Candida albicans Mating
- S. Lachke, S. Lockhart, K. Daniels, D. Soll
- BiologyInfection and Immunity
- 1 September 2003
It was demonstrated that skin facilitates mating and all of the stages of mating observed in vitro were observed in vivo, and some unique morphological characteristics of mating on skin were observed and are attributable to parent cell immobilization on the skin.
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