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Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell-mediated B-cell cytotoxicity.
TLDR
In human lymphoma xenograft models, GA101 exhibits superior antitumor activity, resulting in the induction of complete tumor remission and increased overall survival and in nonhuman primates, GA 101 demonstrates superior B cell-depleting activity in lymphoid tissue, including in lymph nodes and spleen.
Epidermal growth factor system regulates mucin production in airways.
Goblet-cell hyperplasia is a critical pathological feature in hypersecretory diseases of airways. However, the underlying mechanisms are unknown, and no effective therapy exists. Here we show that
Piphillin: Improved Prediction of Metagenomic Content by Direct Inference from Human Microbiomes
TLDR
Piphillin is introduced, a straightforward algorithm independent of any proposed phylogenetic tree, leveraging contemporary functional databases and not obliged to any singular data pre-processing protocol, that demonstrates that functional inference using the direct method implemented in Piphill in is preferable for clinical biospecimens.
IL-4 induces mucin gene expression and goblet cell metaplasia in vitro and in vivo.
TLDR
Results indicate that airway epithelial cells express IL- 4R constitutively and that IL-4 directly induces the differentiation of epithelium into mucous glycoconjugate-containing goblet cells.
Oxidative Stress Causes Mucin Synthesis Via Transactivation of Epidermal Growth Factor Receptor: Role of Neutrophils1
TLDR
It is shown that oxidative stress causes ligand-independent activation of epidermal growth factor receptors (EGFR) and subsequent activation of mitogen-activated protein kinase kinase (MEK), resulting in mucin synthesis in NCI-H292 cells, and new therapeutic approaches in airway hypersecretory diseases are provided.
IL-13 induces mucin production by stimulating epidermal growth factor receptors and by activating neutrophils.
TLDR
Findings indicate that EGFR signaling is involved in IL-13-induced mucin production and suggest a potential therapeutic role for inhibitors of the EGFR cascade in the hypersecretion that occurs in acute asthma.
Genetic segregation of airway disease traits despite redundancy of calcium-activated chloride channel family members.
TLDR
Clca expression appears to be a selective determinant of mucous cell metaplasia so that shared homologies between CLCA family members may still represent a useful target for focused therapeutic intervention in hypersecretory airway disease.
Cigarette smoke synergistically enhances respiratory mucin induction by proinflammatory stimuli.
TLDR
It is suggested that cigarette smoke has the potential to synergistically amplify induction of respiratory mucins by proinflammatory stimuli relevant to COPD pathogenesis and contribute to mucin hyperproduction observed in patients with COPD.
Toll-like receptors and T-helper-1/T-helper-2 responses
TLDR
There is evidence that TLRs may be important for Th2-type responses, possibly by augmenting the overall maturity of dendritic cells, and a greater understanding of the processes by which TLRs regulate adaptive immunity may yield new approaches to the treatment and prevention of allergic and certain autoimmune disorders.
Protease-Activated Receptor 2 Mediates Eosinophil Infiltration and Hyperreactivity in Allergic Inflammation of the Airway1
TLDR
The results support the proposal that tryptase inhibitors and PAR2 antagonists may be useful therapies for inflammatory airway disease.
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