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Physical biochemistry of a liposomal amphotericin B mixture used for patient treatment.
- C. Grant, K. Hamilton, K. D. Hamilton, K. R. Barber
- Chemistry, Medicine
- Biochimica et biophysica acta
- 21 August 1989
Melting curves and derived phase diagrams showed evidence that amphotericin B is relatively immiscible with the solid phase of bilayer membranes, particularly at the highest drug concentrations. Expand
Nutrient deprivation increases vulnerability of endothelial cells to proinflammatory insults.
The findings show a role of mitochondrial enzymes in superoxide production in response to nutrient deprivation and suggest that proinflammatory responses in HUV ECs become manifest when HUVECs are in an already-compromised state. Expand
Evaluation of the composition of omega-3 fatty acids in dietary oil supplements.
Aim: The aim of the present study was to determine the fatty acid composition of 19 dietary oil supplements that are commercially available in Australia, comparing findings with manufacturers'… Expand
Natural products isolated from Tetragonula carbonaria cerumen modulate free radical-scavenging and 5-lipoxygenase activities in vitro
- K. D. Hamilton, P. Brooks, S. Ogbourne, F. Russell
- BMC Complementary and Alternative Medicine
- 26 April 2017
The findings identify free radical scavenging activity, and interference by extracts of T. carbonaria cerumen in 5-LOX–LTB4 signaling, and are needed to determine whether the extracts will provide therapeutic benefits for medical conditions in which oxidative stress and inflammation are implicated. Expand
Evaluation of the anti-inflammatory, anti-oxidant and wound-healing potential of cerumen from the Australian native stingless bee, Tetragonula carbonaria
- K. D. Hamilton
The work described in this thesis aimed to determine the anti-oxidant, anti-inflammatory and wound-healing properties of T. carbonaria cerumen, identify its bioactive constituents; and evaluate its potential to provide benefit in cases of pathological wound- healing. Expand
A methanolic extract of propolis collected from the Australian native stingless bee, Tetragonula carbonaria, scavenges free radicals and inhibits 5-lipoxygenase activity in vitro
- K. D. Hamilton
The polar methanolic extract was dried and reconstituted for use in bioassays and the effect of the extract on the oxidation of linoleic acid (LA) by 5-lipoxygenase was examined using a cell-free colorimetric assay and by examination of Michaelis-Menten kinetics. Expand
Extracts of Australian Native Stingless Bee (Tetragonula Carbonaria) Cerumen Differentially Modulate Dermal Fibroblast and Keratinocyte proliferatin in vitro
Effect of the novel wound healing agent, OPAL A on leukotriene B 4 production in human neutrophils and 5-lipoxygenase activity RussellFD,WindeggerT,HamiltonKD&CheethamNWH
OPAL A is a papaya pulp that is heated and alkalised with bicarbonate (the OPAL process) and is undergoing clinical trials for treatment of chronic wounds. The aim of this study was to investigate… Expand
Extracts of Australian native stingless bee (Tetragonula carbonaria) cerumen modulate dermal fibroblast proliferation and myofibroblast differentiation in vitro
Introduction. Cerumen is a resinous, plant-derived product of stingless bees. We previously identified extracts and fractions of Australian native stingless bee (Tetragonula carbonaria) cerumen with… Expand