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Gap Junctions Mediate Bystander Cell Death in Developing Retina
TLDR
It is hypothesized that dying cells in the retina generate a gap junction-permeant apoptotic signal that mediates bystander killing, and this novel finding of naturally occurring bystander cell death may have important implications in the histogenesis and pathology of the nervous system.
Gap junctions remain open during cytochrome c-induced cell death: relationship of conductance to ‘bystander’ cell killing
TLDR
Electrical coupling following induction of cell death by single-cell cytochrome c injection in paired Xenopus oocytes inhibited bystander cell death in pairs that had reached the death conductance threshold, suggesting that Ca2+ and inositol 1,4,5 triphosphate are involved in the process.
Rods and cones project to the inner plexiform layer during development
TLDR
It is demonstrated that, despite the clear presence of environmental signals presaging the formation of the OPL, photoreceptor terminals initially ignore them to grow beyond this level of the retina, and detect and respond to signals within the IPL during this period.
Organization of the inner retina following early elimination of the retinal ganglion cell population: Effects on cell numbers and stratification patterns
TLDR
The present results demonstrate a class-specific dependency of inner retinal neurons upon the ganglion cell population in early postnatal life, but theganglion cells do not appear to provide any critical signals for stratification within the inner plexiform layer, at least not after birth.
Hypoglycemia leads to age-related loss of vision
TLDR
Linkage between low blood glucose and loss of vision in mice may highlight the importance for glycemic control in diabetics and retinal diseases related to metabolic stress as macular degeneration.
A developmental switch in the expression of aquaporin-4 and Kir4.1 from horizontal to Müller cells in mouse retina.
TLDR
The findings showed that AQP4 and Kir4.1 protein expression is confined to differentiating horizontal cells before its expression in Müller cells, which suggests that these cells mediate K(+) and water transcellular uptake until the initiation of phototransduction, when glial cells assume these functions.
Depletion of calcium stores regulates calcium influx and signal transmission in rod photoreceptors
TLDR
SOCE modulates Ca2+ homeostasis and light‐evoked neurotransmission at the rod photoreceptor synapse mediated by TRPC1, and is required to maintain baseline [Ca2+]i in rod inner segments and synaptic terminals.
Cell death in the inner nuclear layer of the retina is modulated by BDNF.
TLDR
It is shown that providing BDNF or decreasing endogenous BDNF via competitive binding with soluble TrkB receptors in a whole-retina culture assay modulates the frequency of dying cells in the amacrine cell layer.
Cellular positioning and dendritic field size of cholinergic amacrine cells are impervious to early ablation of neighboring cells in the mouse retina
TLDR
Results show that cholinergic amacrine cells normally increase their dendritic field area after P-3 in excess of retinal expansion; despite this, the present results show that this growth is not controlled by the density of neighboring processes.
Monitoring mouse retinal degeneration with high-resolution spectral-domain optical coherence tomography.
TLDR
It is shown that SD-OCT can monitor the progression of retinal degeneration in transgenic mice and resolve all the major layers of the retina of control C57BL/6J mice.
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