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Distribution of serotonin 5-HT2C receptors in the ventral tegmental area
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College on Problems of Drug Dependence
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Influence of ovarian hormones and estrous cycle on the behavioral response to cocaine in female rats.
TLDR
It is demonstrated that E significantly influences the responsiveness of female rats to cocaine, and the enhanced response to cocaine was demonstrated in the presence of pharmacologically administered E as well as correlated with the normal estrous cycle.
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Estrogen regulation of gene expression in the brain: a possible mechanism altering the response to psychostimulants in female rats.
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Serotonin2C receptor localization in GABA neurons of the rat medial prefrontal cortex: Implications for understanding the neurobiology of addiction
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Pharmacological studies of the acute and chronic effects of (+)-3, 4-methylenedioxymethamphetamine on locomotor activity: role of 5-hydroxytryptamine(1A) and 5-hydroxytryptamine(1B/1D) receptors.
TLDR
A role for 5-HT(1B/1D) in mediating the acute hyperactivity evoked by (+)- MDMA is supported, and the development of sensitization to (+)-MDMA was associated with supersensitivity to a 5- HT(1 B/1A) agonist, suggesting that these receptors may contribute to sensitization.
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Blockade of the serotonin 5-HT2A receptor suppresses cue-evoked reinstatement of cocaine-seeking behavior in a rat self-administration model.
TLDR
The findings indicate that blockade of the 5-HT-sub(2A)R attenuates the incentive-motivational effects of cocaine-paired cues, particularly in high extinction responders, and suggests that M100907 may afford a therapeutic advance in suppression of cue-evoked craving and/or relapse.
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Effects of dopamine D1- or D2-like receptor antagonists on the hypermotive and discriminative stimulus effects of (+)-MDMA
TLDR
DA released indirectly by (+)-MDMA administration results in stimulation of D1R and D2R to enhance locomotor activity, and the D1r appears to play a more prominent role than the D2r in the discriminative stimulus properties of (+)- MDMA.
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Antagonism of 5-hydroxytryptamine(2a) receptors attenuates the behavioral effects of cocaine in rats.
TLDR
It is suggested that 5-HT2A receptors play an important role in the behavioral effects of cocaine and that they should be considered a viable target for analysis in the search for pharmacotherapies useful in the treatment of cocaine dependence.
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Differential Regulation of the Mesoaccumbens Circuit by Serotonin 5-Hydroxytryptamine (5-HT)2A and 5-HT2CReceptors
TLDR
These findings are the first to demonstrate that the behavioral effects of cocaine are generated in part by activation of 5-HT2ARs in the VTA and byactivation of 4-trifluoromethylphenylsulfon-amido)phenyl-5-oxopentyl in the NAc shell.
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