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Bigeneric initial ideals, diagonal subalgebras and bigraded Hilbert functions
The peaks and geometry of fitness landscapes.
Designing Antibiotic Cycling Strategies by Determining and Understanding Local Adaptive Landscapes
It is shown that alternating structurally similar antibiotics can restore susceptibility to antibiotics after resistance has evolved, and this approach may also guide sustainable cycling of the drugs used to treat malaria and HIV.
Rational Design of Antibiotic Treatment Plans: A Treatment Strategy for Managing Evolution and Reversing Resistance
Overall this study shows that there is promise for reversing the evolution of resistance through antibiotic treatment plans, and identified optimized treatment paths that returned the highest probabilities of selecting for reversions of amino acid substitutions and returning TEM to the wild type state.
Inferring genetic interactions from comparative fitness data
Darwinian fitness is a central concept in evolutionary biology. In practice, however, it is hardly possible to measure fitness for all genotypes in a natural population. Here, we present quantitative…
Correction: Rational Design of Antibiotic Treatment Plans: A Treatment Strategy for Managing Evolution and Reversing Resistance
- Portia Mira, K. Crona, Devin Greene, J. Meza, B. Sturmfels, M. Barlow
- MedicinePloS one
- 24 September 2015
There is an error in the caption for Fig 1, " AMP: Ampicillin 256 μg/ml. " Please see the corrected Fig 1 here. There are errors in the caption for Fig 14, " TZP: Pipercillin / Tazobactam 8.12μg/ml…
The Changing Geometry of a Fitness Landscape Along an Adaptive Walk
It is shown that the relative prevalence of the various kinds of epistasis varies along an adaptive walk, and a simple and general explanation is proposed, confirming the role of mean regression.
Troxonium-like inhibitors of the high affinity uptake of choline in mouse brain synaptosomes in vitro.
Rank orders and signed interactions in evolutionary biology
- K. Crona
- 14 January 2020
The previous work on inferring genetic interactions from comparative fitness data is related to an influential approach to rank orders based on sign epistasis that depends on order perturbations that indicate interactions that are prevalent in the antimalarial drug-resistance landscape.
Recombination and peak jumping
- K. Crona
- BiologyPloS one
- 7 November 2014
It is shown that genetic recombination can be a powerful mechanism for escaping suboptimal peaks and can be considered a support for Sewall Wright's view that adaptation sometimes works better in subdivided populations.