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A new and rapid colorimetric determination of acetylcholinesterase activity.
A photometric method for determining acetylcholinesterase activity of tissue extracts, homogenates, cell suspensions, etc., has been described and Kinetic constants determined by this system for erythrocyte eholinesterases are presented. Expand
The PI3K pathway as drug target in human cancer.
This review will discuss how PI3K signaling affects the growth and survival of tumor cells and consider how inhibitors of this pathway, either alone or in combination with other therapeutics, can be used for the treatment of cancer. Expand
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
It is shown that expression of PKM1, the pyruvate kinase isoform with high constitutive activity, or exposure to published small molecule PKM2 activators inhibit growth of xenograft tumors and support the notion that small molecule activation ofPKM2 can interfere with anabolic metabolism. Expand
Hexachlorobenzene (HCB): a review.
  • K. Courtney
  • Biology, Medicine
  • Environmental research
  • 1 December 1979
HCB is a global pollutant that is known to have a high degree of toxicity in human beings and other species and its use and disposal should be carefully monitored. Expand
Targeting renal cell carcinoma with a HIF-2 antagonist
It is shown that some ccRCCs are HIF-2 independent, and set the stage for biomarker-driven clinical trials, using a tumourgraft/patient-derived xenograft platform to evaluate PT2399, a selective Hif-2 antagonist that was identified using a structure-based design approach. Expand
Localization and Phosphorylation of Abl-Interactor Proteins, Abi-1 and Abi-2, in the Developing Nervous System
The Abi adaptors exhibit proper expression patterns and subcellular localization to participate in Abl kinase signaling in the nervous system. Expand
Teratology studies with 2,4,5-trichlorophenoxyacetic acid and 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Prenatal administration of 2,4,5-T did not affect the postnatal growth and development of the CD rat, and when these compounds were administered in combination, the activity was not potentiated at the doses employed. Expand
Analysis of the biologic properties of p230 Bcr-Abl reveals unique and overlapping properties with the oncogenic p185 and p210 Bcr-Abl tyrosine kinases.
It is suggested that the different Bcr-Abl fusion proteins drive the expansion of different hematopoietic populations, which may explain the association of the various Bcr -Abl oncoproteins with different spectra of human leukemias. Expand
HIF-2 Complex Dissociation, Target Inhibition, and Acquired Resistance with PT2385, a First-in-Class HIF-2 Inhibitor, in Patients with Clear Cell Renal Cell Carcinoma
Findings demonstrate a core dependency on Hif-2 in metastatic ccRCC and establish PT2385 as a highly specific HIF-2 inhibitor in humans and establish new approaches will be required to target mutant H IF-2 beyondPT2385 or the closely related PT2977. Expand
The effects of pentachloronitrobenzene, hexachlorobenzene, and related compounds on fetal development.
Purified PCNB showed more maternal toxicity than the contaminated PCNB and resulted in a few cleft palates in the fetuses; there were no kidney malformations with purified PCNB, so the teratogenic activity of contaminated PC NB was probably due to the HCB. Expand