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Reactive oxygen species (ROS) are involved in enhancement of NMDA-receptor phosphorylation in animal models of pain
Abstract Recent studies indicate that reactive oxygen species (ROS) play an important role in neuropathic pain, predominantly through spinal mechanisms. Since the data suggest that ROS are involvedExpand
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Sympathetic sprouting in the dorsal root ganglia of the injured peripheral nerve in a rat neuropathic pain model
The extent of the sprouting of sympathetic postganglionic fibers in the dorsal root ganglion (DRG) and the peripheral nerves was examined in neuropathic rats at different postoperative times. AfterExpand
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Enhancement of NMDA receptor phosphorylation of the spinal dorsal horn and nucleus gracilis neurons in neuropathic rats
&NA; NR1 is an essential component of functional NMDA receptors and can be activated by phosphorylation. It is suggested that phosphorylation of NR1 (pNR1) contributes to central sensitization afterExpand
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A study of axonal diameters and areas in lumbosacral roots and nerves in the rat
There has been debate as to whether there is a size difference between central and peripheral processes of dorsal root ganglion cells. In the present study, the mean areas of myelinated andExpand
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The effects of dorsal rhizotomy and spinal cord isolation on calcitonin gene-related peptide-labeled terminals in the rat lumbar dorsal horn
In the present study, the origin of calcitonin gene-related peptide (CGRP) to the dorsal horn in the rat lumbar spinal cord is investigated. CGRP immunoreactivity is examined following multipleExpand
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Abnormalities of sympathetic innervation in the area of an injured peripheral nerve in a rat model of neuropathic pain
Using the rat model that we have developed, a potential underlying mechanism for sympathetically maintained neuropathic pain (SMP) was explored. In rats showing neuropathic pain behaviors after aExpand
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The role of reactive oxygen species in capsaicin-induced mechanical hyperalgesia and in the activities of dorsal horn neurons
Abstract Previous findings that reactive oxygen species (ROS) are involved in neuropathic pain, mainly through spinal mechanisms, suggest that ROS may be involved in central sensitization. ToExpand
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Postnatal development of the rat dorsal funiculus
The present study shows that there are approximately 21,000 axons in the neonatal rat dorsal funiculus, as compared to 26,000 in 2-week-old animals. We attribute this increase primarily to arrivingExpand
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Regulation of Wnt signaling by nociceptive input in animal models
BackgroundCentral sensitization-associated synaptic plasticity in the spinal cord dorsal horn (SCDH) critically contributes to the development of chronic pain, but understanding of the underlyingExpand
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A light and electron microscopic level analysis of calcitonin gene-related peptide (CGRP) in the spinal cord of the primate: An immunohistochemical study
In the present study, the distribution of calcitonin gene-related peptide (CGRP)-stained fibers and varicosities are demonstrated in the lumbar spinal cord of the monkey at the light microscopicExpand
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