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International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
Recommendations and guidelines on the evaluation and treatment of severe asthma in children and adults and coordinated research efforts for improved phenotyping will provide safe and effective biomarker-driven approaches to severe asthma therapy are provided.
Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program.
- W. Moore, D. Meyers, E. Bleecker
- MedicineAmerican journal of respiratory and critical care…
- 15 February 2010
Five distinct clinical phenotypes of asthma have been identified using an unsupervised hierarchical cluster analysis, which supports clinical heterogeneity in asthma and the need for new approaches for the classification of disease severity in asthma.
ERS guidelines on the assessment of cough
Cough can have profound effects on health status, which can be assessed by cough-specific health status questionnaires, and may be used to follow change in cough reflex sensitivity in an individual.
Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsìveness, and the late asthmatic response
Inflammatory mediators of asthma: an update.
Prevalence, pathogenesis, and causes of chronic cough
Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction
The mechanisms of chronic obstructive pulmonary disease may be heterogeneous, according to severity, and clinical phenotypes need to be correlated with cellular and pathological processes, and treatments may be targeted to patients with specific mechanisms.
Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages.
- K. Ito, S. Lim, G. Caramori, K. Chung, P. Barnes, I. Adcock
- BiologyFASEB journal : official publication of the…
- 1 April 2001
It is shown that cigarette smoke, an oxidative stress, decreased HDAC activity in human biopsies and macrophages in vivo and this reduced activity correlated with enhanced induction of inflammatory cytokines and a reduction in glucocorticoid responsiveness in vitro.
Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma.
Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma.
The correlation between exhaled No and PC20 suggests that exhaled NO or the mechanisms leading to its increase may contribute to airway hyperresponsiveness in asthma.