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Faustian bargains? Restoration realities in the context of biodiversity offset policies
The science and practice of ecological restoration are increasingly being called upon to compensate for the loss of biodiversity values caused by development projects. BiodiversityExpand
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PTEN Inhibition to Facilitate Intrinsic Regenerative Outgrowth of Adult Peripheral Axons
In vivo regeneration of peripheral neurons is constrained and rarely complete, and unfortunately patients with major nerve trunk transections experience only limited recovery. IntracellularExpand
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Modulation of locomotor activity by multiple 5-HT and dopaminergic receptor subtypes in the neonatal mouse spinal cord.
Recently, it has been shown that bath-applied 5-HT can elicit fictive locomotion from perinatal mouse preparations. Since 5-HT acts on multiple receptor subtypes, the focus of this study was toExpand
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Schwann cells direct peripheral nerve regeneration through the Netrin‐1 receptors, DCC and Unc5H2
In the peripheral nervous system, Schwann cells (SCs) promote nerve regeneration by the secretion of trophic support molecules and the establishment of a supportive growth matrix. Elucidating factorsExpand
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Oligodendrocyte Birth and Death following Traumatic Brain Injury in Adult Mice
Oligodendrocytes are responsible for producing and maintaining myelin throughout the CNS. One of the pathological features observed following traumatic brain injury (TBI) is the progressiveExpand
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Regulation of endogenous neural stem/progenitor cells for neural repair—factors that promote neurogenesis and gliogenesis in the normal and damaged brain
Neural stem/precursor cells in the adult brain reside in the subventricular zone (SVZ) of the lateral ventricles and the subgranular zone (SGZ) of the dentate gyrus in the hippocampus. These cellsExpand
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Monoaminergic establishment of rostrocaudal gradients of rhythmicity in the neonatal mouse spinal cord.
Bath application of monoamines is a potent method for evoking locomotor activity in neonatal rats and mice. Monoamines also promote functional recovery in adult animals with spinal cord injuries byExpand
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Disruption of E3 ligase NEDD4 in peripheral neurons interrupts axon outgrowth: Linkage to PTEN
Exploiting molecules and pathways important in developmental axon behaviour may offer new insights into regenerative behaviour of adult peripheral neurons after injury. In previous work, we haveExpand
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Adult hippocampal neurogenesis, Rho kinase inhibition and enhancement of neuronal survival
Adult neurogenesis occurs throughout life; however the majority of new neurons do not survive. Enhancing the survival of these new neurons will increase the likelihood that these neurons could returnExpand
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ENHANCING ADULT NERVE REGENERATION THROUGH THE KNOCKDOWN OF RETINOBLASTOMA PROTEIN
Tumour suppressor pathways may offer novel targets capable of altering the plasticity of post-mitotic adult neurons. Here we describe a role for retinoblastoma (Rb) protein, widely expressed in adultExpand
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