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Expansion and characterization of cancer stem-like cells in squamous cell carcinoma of the head and neck.
This work reports the identification, expansion, and characterization of CD44+ cancer stem-like cells from a permanent squamous cell carcinoma of the head and neck (SCCHN) cell line and indicates that a subpopulation of CSCs is maintained in the SCCHN cell line, and the presence of such C SCs has an important clinical implication for head and head cancer treatment. Expand
Cancer-associated fibroblasts promote an immunosuppressive microenvironment through the induction and accumulation of protumoral macrophages
It is indicated that CAFs play important roles in shaping the tumor immunosuppressive microenvironment in OSCC by inducing the protumoral phenotype of TAMs andTherapeutic strategies to reverse CAF-mediated Immunosuppression need to be considered. Expand
Immunosuppressive activity of CD14+ HLA‐DR− cells in squamous cell carcinoma of the head and neck
The data suggest that CD14+ HLA‐DR− cells act as potent immunosuppressive cells and particularly contribute to tumor escape from the host immune system in patients with SCCHN. Expand
Immunosuppressive activity of cancer-associated fibroblasts in head and neck squamous cell carcinoma
It is demonstrated that CAFs collaborated with tumor cells in the TME to establish an immunosuppressive network that facilitated tumor evasion from immunological destruction. Expand
Maturation of circulating dendritic cells and imbalance of T-cell subsets in patients with squamous cell carcinoma of the head and neck
The results suggest that the decreased proportion of circulating DCs and decreased HLA-DR expression in DCs may have a major impact on systemic immune responses in patients with SCCHN. Expand
Immunoregulatory properties of CD44+ cancer stem‐like cells in squamous cell carcinoma of the head and neck
CD44 was found as a surface marker in cancer stem cell (CSC) of squamous cell carcinoma of the head and neck (SCCHN); however, the immunologic properties of such CSCs have not yet been elucidated.
Immune responses to p53 in patients with cancer:enrichment in tetramer+ p53 peptide-specific T cells and regulatory T cells at tumor sites
Anti-wt p53 epitope-specific T cells and Treg preferentially localize to tumor sites in patients with HNC, but the effector cell population in TIL or PBMC was unresponsive to activation in the tumor microenvironment enriched in Treg. Expand
Clinical significance of p53 functional loss in squamous cell carcinoma of the oropharynx
It is concluded that p53 mutation is associated with radiation resistance and a decreased probability of survival in oropharyngeal SCC. Expand
Nivolumab-induced hypophysitis in a patient with advanced malignant melanoma.
The present report provides the first detailed endocrinological presentation of nivolumab-induced hypophysitis showing the enlargement of the pituitary gland and stalk in a malignant melanoma patient in Japan. Expand
Relationships between regulatory T cells and CD8+ effector populations in patients with squamous cell carcinoma of the head and neck
The balance between type 1 and type 2 T‐cell subsets in cancer patients is thought to modulate antitumor immunity and CD4+CD25+ regulatory T cells (Treg), which are potent inhibitors of antitumors immune responses, also play an invaluable role in maintaining immune homeostasis. Expand