Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
- S. Grissmer, A. N. Nguyen, K. Chandy
- BiologyMolecular Pharmacology
- 1 June 1994
We have analyzed the biophysical and pharmacological properties of five cloned K+ (Kv) channels (Kv1.1, Kv1.2, Kv1.3, Kv1.5, and Kv3.1) stably expressed in mammalian cell lines. Kv1.1 is…
The functional network of ion channels in T lymphocytes
- M. Cahalan, K. Chandy
- BiologyImmunological Reviews
- 1 September 2009
The expression pattern of Ca2+ and K+ channels and hence the functional network can adapt depending upon the state of differentiation and activation, and this allows for different stages of an immune response to be targeted specifically.
Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant.
- H. Wulff, M. Miller, W. Hansel, S. Grissmer, M. Cahalan, K. Chandy
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 5 July 2000
TRAM-34 (1-[(2-chlorophenyl)diphenylmethyl]-1H-pyrazole) inhibits the cloned and the native IKCa1 channel in human T lymphocytes with a K(d) of 20-25 nM and is 200- to 1,500-fold selective over other ion channels, suggesting that TRAM- 34 and related compounds may hold therapeutic promise as immunosuppressants.
International Union of Pharmacology. LII. Nomenclature and Molecular Relationships of Calcium-Activated Potassium Channels
- A. Wei, G. Gutman, R. Aldrich, K. Chandy, S. Grissmer, H. Wulff
- BiologyPharmacological Reviews
- 1 December 2005
The first cloned potassium channel gene was the Drosophila voltage-gated shaker channel, and this was rapidly followed by the identification of other potassium channel genes.
International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels.
- A. Wei, G. Gutman, R. Aldrich, K. Chandy, S. Grissmer, H. Wulff
- BiologyPharmacological Reviews
- 2005
Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri (A.D.A.G.) and Physiology and Biophysics (K.W.G).
K+ channels as targets for specific immunomodulation.
- K. Chandy, H. Wulff, C. Beeton, M. Pennington, G. Gutman, M. Cahalan
- BiologyTIPS - Trends in Pharmacological Sciences
- 1 May 2004
International Union of Pharmacology. LIII. Nomenclature and Molecular Relationships of Voltage-Gated Potassium Channels
- G. Gutman, K. Chandy, Xiaoliang Wang
- BiologyPharmacological Reviews
- 1 December 2005
Department of Microbiology and Molecular Genetics (G.A.G.) and Physiology and Biophysics (K.R.C.) and Institute of Materia Medica, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing, China.
Molecular Properties and Physiological Roles of Ion Channels in the Immune System
- M. Cahalan, H. Wulff, K. Chandy
- BiologyJournal of Clinical Immunology
- 1 July 2001
This review surveys recent progress at the biophysical, molecular, and functional roles of the ion channels found in T lymphocytes, including K+, Ca2+, and Cl− channels.
Up-regulation of the IKCa1 Potassium Channel during T-cell Activation
- S. Ghanshani, H. Wulff, K. Chandy
- BiologyJournal of Biological Chemistry
- 24 November 2000
Kv1.3 channels are essential for activation of quiescent cells, but signaling through the PKC pathway enhances expression of IKCa1 channels that are required for continued proliferation.
Blockade of the Intermediate-Conductance Calcium-Activated Potassium Channel as a New Therapeutic Strategy for Restenosis
Blockade of IKCa1 could represent a new therapeutic strategy to prevent restenosis after angioplasty and promote excessive neointimal VSMC proliferation.
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