• Publications
  • Influence
Geographic variation in opioid prescribing in the U.S.
UNLABELLED Estimates of geographic variation among states and counties in the prevalence of opioid prescribing are developed using data from a large (135 million) representative national sample ofExpand
  • 202
  • 8
Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein
Significance Pepducins are a class of biologics that allosterically control G protein-coupled receptor (GPCR) activity, but very little is known about their mode of action. Here, we report thatExpand
  • 91
  • 6
  • PDF
Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells
The G protein-coupled receptor (GPCR), chemokine CXC-type receptor 4 (CXCR4), and its ligand, CXCL12, mediate the retention of polymorphonuclear neutrophils (PMNs) and hematopoietic stem andExpand
  • 80
  • 4
  • PDF
Estimating the Prevalence of Opioid Diversion by “Doctor Shoppers” in the United States
Background Abuse of prescription opioid analgesics is a serious threat to public health, resulting in rising numbers of overdose deaths and admissions to emergency departments and treatmentExpand
  • 81
  • 3
  • PDF
A selective small molecule agonist of the melanocortin‐1 receptor inhibits lipopolysaccharide‐induced cytokine accumulation and leukocyte infiltration in mice
It is well established that melanocortins are peptides that have potent anti‐inflammatory activity. Recent research has focused on understanding which of the known melanocortin receptors mediates theExpand
  • 34
  • 3
Sodium salicylate inhibits TNF-&agr;-induced NF-κB activation, cell migration, invasion and ICAM-1 expression in human melanoma cells
We have previously shown that tumour necrosis factor-alpha (TNF-&agr;) upregulates human melanoma cell integrin expression, migration and invasion in vitro. The aim of this study was to investigateExpand
  • 28
  • 2
Dual angiotensin II and endothelin A receptor antagonists: synthesis of 2'-substituted N-3-isoxazolyl biphenylsulfonamides with improved potency and pharmacokinetics.
In a previous report we demonstrated that merging together key structural elements present in an AT(1) receptor antagonist (1, irbesartan) with key structural elements in a biphenylsulfonamide ET(A)Expand
  • 58
  • 1
Discovery of tyrosine-based potent and selective melanocortin-1 receptor small-molecule agonists with anti-inflammatory properties.
The melanocortin-1 receptor (MC-1R) is a G-protein-coupled receptor involved in inflammation and skin pigmentation. Compound 2 is the first highly potent and selective MC-1R small-molecule agonistExpand
  • 50
  • 1
The ecology of prescription opioid abuse in the USA: geographic variation in patients' use of multiple prescribers (“doctor shopping”)
This study estimates the prevalence in US counties of opioid patients who use large numbers of prescribers, the amounts of opioids they obtain, and the extent to which their prevalence is predictedExpand
  • 30
  • 1
Discovery of pyrazine carboxamide CB1 antagonists: the introduction of a hydroxyl group improves the pharmaceutical properties and in vivo efficacy of the series.
Structure-activity relationships for a series of pyrazine carboxamide CB1 antagonists are reported. Pharmaceutical properties of the series are improved via inclusion of hydroxyl-containingExpand
  • 29
  • 1