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Expression systems for heterologous production of antimicrobial peptides
Antimicrobial peptides (AMPs) consist of molecules that act on the defense systems of numerous organisms toward multiple pathogens such as bacteria, fungi, parasites and viruses. These compounds haveExpand
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Current scenario of peptide-based drugs: the key roles of cationic antitumor and antiviral peptides
Cationic antimicrobial peptides (AMPs) and host defense peptides (HDPs) show vast potential as peptide-based drugs. Great effort has been made in order to exploit their mechanisms of action, aimingExpand
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Production of a modified peptide clavanin in Pichia pastoris: cloning, expression, purification and in vitro activities
AbstractAntimicrobial peptides are one of the most promising peptide-based drugs due to their enormous potential as novel biopharmaceuticals in both human and animal industries. In order to developExpand
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Lovastatin production: From molecular basis to industrial process optimization.
Lovastatin, composed of secondary metabolites produced by filamentous fungi, is the most frequently used drug for hypercholesterolemia treatment due to the fact that lovastatin is a competitiveExpand
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Production of a polar fish antimicrobial peptide in Escherichia coli using an ELP-intein tag.
An important aspect related to infectious pathogens is their exceptional adaptability in developing resistance, which leads to a perpetual challenge in the discovery of antimicrobial drugs with novelExpand
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Novel homologous lactate transporter improves l-lactic acid production from glycerol in recombinant strains of Pichia pastoris
BackgroundCrude glycerol is the main byproduct of the biodiesel industry. Although it can have different applications, its purification is costly. Therefore, in this study a biotechnological routeExpand
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Effect of Pyruvate Decarboxylase Knockout on Product Distribution Using Pichia pastoris (Komagataella phaffii) Engineered for Lactic Acid Production
Lactic acid is the monomer unit of the bioplastic poly-lactic acid (PLA). One candidate organism for lactic acid production is Pichia pastoris, a yeast widely used for heterologous proteinExpand
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Exploring the Pharmacological Potential of Promiscuous Host-Defense Peptides: From Natural Screenings to Biotechnological Applications
In the last few years, the number of bacteria with enhanced resistance to conventional antibiotics has dramatically increased. Most of such bacteria belong to regular microbial flora, becoming a realExpand
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Construction of an artificial secYEG operon allowing high level secretion of α-amylase.
The key components of the major secretion pathway in bacteria, the Sec pathway, are the proteins SecA, an ATPase that generates the energy required for protein translocation, and the heterotrimericExpand
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Critical aspects to be considered prior to large-scale production of peptides.
Numerous peptides are available on the market as therapeutic drugs for regulating tumor growth, microorganism proliferation, immune response and/or metabolic disorders. Peptides are produced eitherExpand
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