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Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus
Little is known about the mechanism by which IFNs inhibit human cytomegalovirus (HCMV) replication. Indeed, infection of fibroblasts with HCMV initiates the expression of a subset of type IExpand
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Host Gene Expression Profiling of Dengue Virus Infection in Cell Lines and Patients
Background Despite the seriousness of dengue-related disease, with an estimated 50–100 million cases of dengue fever and 250,000–500,000 cases of dengue hemorrhagic fever/dengue shock syndrome eachExpand
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Transcriptional Scaffold: CIITA Interacts with NF-Y, RFX, and CREB To Cause Stereospecific Regulation of the Class II Major Histocompatibility Complex Promoter
ABSTRACT Scaffold molecules interact with multiple effectors to elicit specific signal transduction pathways. CIITA, a non-DNA-binding regulator of class II major histocompatibility complex (MHC)Expand
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TLR3 Ligation Activates an Antiviral Response in Human Fetal Astrocytes: A Role for Viperin/cig51
TLR3 functions as a viral nucleic acid sentinel activated by dsRNA viruses and virus replication intermediates within intracellular vesicles. To explore the spectrum of genes induced in humanExpand
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The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin
A cytosolic role for the histone methyltransferase Ezh2 in regulating lymphocyte activation has been suggested, but the molecular mechanisms underpinning this extranuclear function have remainedExpand
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In vivo and in vitro studies on the antiviral activities of viperin against influenza H1N1 virus infection.
Influenza A virus has caused a number of pandemics in past decades, including the recent H1N1-2009 pandemic. Viperin is an interferon (IFN)-inducible protein of innate immunity, and acts as aExpand
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Mesenchymal stromal cell exosome-enhanced regulatory T-cell production through an antigen-presenting cell-mediated pathway.
BACKGROUND AIMS The immunomodulatory property of mesenchymal stromal cell (MSC) exosomes is well documented. On the basis of our previous report that MSC exosomes increased regulatory T-cell (Treg)Expand
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In vivo and in vitro studies on the antiviral activities of viperin against influenza H 1 N 1 virus infection
Received 22 December 2011 Accepted 28 February 2012 Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, Kent Ridge, Singapore 117597Expand
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The role of BLIMP1 in lymphomagenesis
C75 The discovery of frequent inactivation of BLIMP1 in activated B cell-like DLBCL indicates that BLIMP1 has an important role in the pathogenesis of this lymphoma subtype , and possibly functionsExpand