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Circulating Mitochondrial DAMPs Cause Inflammatory Responses to Injury
Injury causes a systemic inflammatory response syndrome (SIRS) that is clinically much like sepsis. Microbial pathogen-associated molecular patterns (PAMPs) activate innate immunocytes through… Expand
Acute traumatic coagulopathy
Purpose of review Recent therapeutic and observational studies have demonstrated improved survival with better management of haemostasis early after injury. This review delineates our current… Expand
The coagulopathy of trauma: a review of mechanisms.
BACKGROUND Bleeding is the most frequent cause of preventable death after severe injury. Coagulopathy associated with severe injury complicates the control of bleeding and is associated with… Expand
Acute Traumatic Coagulopathy: Initiated by Hypoperfusion: Modulated Through the Protein C Pathway?
- K. Brohi, M. Cohen, M. Ganter, M. Matthay, R. Mackersie, J. Pittet
- Annals of surgery
- 1 May 2007
Objectives:Coagulopathy following major trauma is conventionally attributed to activation and consumption of coagulation factors. Recent studies have identified an acute coagulopathy present on… Expand
Functional definition and characterization of acute traumatic coagulopathy
Objective:To identify an appropriate diagnostic tool for the early diagnosis of acute traumatic coagulopathy and validate this modality through prediction of transfusion requirements in trauma… Expand
Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis.
BACKGROUND Coagulopathy is present at admission in 25% of trauma patients, is associated with shock and a 5-fold increase in mortality. The coagulopathy has recently been associated with systemic… Expand
Acute coagulopathy of trauma: mechanism, identification and effect
Purpose of reviewAcute coagulopathy of trauma has only been described relatively recently. Developing early in the postinjury phase, it is associated with increased transfusion requirements and poor… Expand
Circulating histones are mediators of trauma-associated lung injury.
- S. Abrams, N. Zhang, +9 authors C. Toh
- American journal of respiratory and critical care…
- 15 January 2013
RATIONALE Acute lung injury is a common complication after severe trauma, which predisposes patients to multiple organ failure. This syndrome largely accounts for the late mortality that arises and… Expand
The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial.
BACKGROUND The aim of the CRASH-2 trial was to assess the effects of early administration of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with… Expand
The incidence and magnitude of fibrinolytic activation in trauma patients
- I. Raza, R. Davenport, +12 authors K. Brohi
- Journal of thrombosis and haemostasis : JTH
- 1 February 2013
Summary. Background: Trauma is a global disease, with over 2.5 million deaths annually from hemorrhage and coagulopathy. Overt hyperfibrinolysis is rare in trauma, and is associated with massive… Expand