• Publications
  • Influence
Circulating Mitochondrial DAMPs Cause Inflammatory Responses to Injury
Injury causes a systemic inflammatory response syndrome (SIRS) that is clinically much like sepsis. Microbial pathogen-associated molecular patterns (PAMPs) activate innate immunocytes throughExpand
  • 2,281
  • 186
  • PDF
Acute traumatic coagulopathy
Purpose of review Recent therapeutic and observational studies have demonstrated improved survival with better management of haemostasis early after injury. This review delineates our currentExpand
  • 939
  • 54
The coagulopathy of trauma: a review of mechanisms.
BACKGROUND Bleeding is the most frequent cause of preventable death after severe injury. Coagulopathy associated with severe injury complicates the control of bleeding and is associated withExpand
  • 781
  • 45
  • PDF
Acute Traumatic Coagulopathy: Initiated by Hypoperfusion: Modulated Through the Protein C Pathway?
Objectives:Coagulopathy following major trauma is conventionally attributed to activation and consumption of coagulation factors. Recent studies have identified an acute coagulopathy present onExpand
  • 676
  • 39
  • PDF
Functional definition and characterization of acute traumatic coagulopathy
Objective:To identify an appropriate diagnostic tool for the early diagnosis of acute traumatic coagulopathy and validate this modality through prediction of transfusion requirements in traumaExpand
  • 406
  • 36
Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis.
BACKGROUND Coagulopathy is present at admission in 25% of trauma patients, is associated with shock and a 5-fold increase in mortality. The coagulopathy has recently been associated with systemicExpand
  • 661
  • 28
  • PDF
Acute coagulopathy of trauma: mechanism, identification and effect
Purpose of reviewAcute coagulopathy of trauma has only been described relatively recently. Developing early in the postinjury phase, it is associated with increased transfusion requirements and poorExpand
  • 489
  • 28
  • PDF
Circulating histones are mediators of trauma-associated lung injury.
RATIONALE Acute lung injury is a common complication after severe trauma, which predisposes patients to multiple organ failure. This syndrome largely accounts for the late mortality that arises andExpand
  • 320
  • 26
The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial.
BACKGROUND The aim of the CRASH-2 trial was to assess the effects of early administration of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients withExpand
  • 775
  • 18
  • PDF
The incidence and magnitude of fibrinolytic activation in trauma patients
Summary.  Background: Trauma is a global disease, with over 2.5 million deaths annually from hemorrhage and coagulopathy. Overt hyperfibrinolysis is rare in trauma, and is associated with massiveExpand
  • 315
  • 18
  • PDF