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A classical enzyme active center motif lacks catalytic competence until modulated electrostatically.
- S. Pinitglang, A. Watts, K. Brocklehurst
- Chemistry, BiologyBiochemistry
- 19 August 1997
The cysteine proteinase superfamily is a source of natural structural variants of value in the investigation of mechanism. It has long been considered axiomatic that catalytic competence of these…
A reporter group delivery system with both absolute and selective specificity for thiol groups and an improved fluorescent probe containing the 7-nitrobenzo-2-oxa-1,3-diazole moiety.
- T. Stuchbury, M. Shipton, H. Suschitzky
- ChemistryThe Biochemical journal
- 1 November 1975
TLDR
The activity of the tissue inhibitors of metalloproteinases is regulated by C-terminal domain interactions: a kinetic analysis of the inhibition of gelatinase A.
- F. Willenbrock, T. Crabbe, G. Murphy
- Biology, Computer ScienceBiochemistry
- 27 April 1993
TLDR
Comparative studies on the 5-aminolaevulinic acid dehydratases from Pisum sativum, Escherichia coli and Saccharomyces cerevisiae.
- N. Senior, K. Brocklehurst, M. Warren
- BiologyThe Biochemical journal
- 1 December 1996
TLDR
Demonstration that 1-trans-epoxysuccinyl-L-leucylamido-(4-guanidino) butane (E-64) is one of the most effective low Mr inhibitors of trypsin-catalysed hydrolysis. Characterization by kinetic analysis…
- S. Sreedharan, C. Verma, K. Brocklehurst
- Biology, ChemistryThe Biochemical journal
- 15 June 1996
1-trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butane (E-64) was shown to inhibit beta-trypsin by a reversible competitive mechanism; this contrasts with the widely held view that E-64 is a…
Structural insights into substrate specificity and the anti beta-elimination mechanism of pectate lyase.
- A. Seyedarabi, T. T. To, R. Pickersgill
- Biology, ChemistryBiochemistry
- 26 January 2010
TLDR
Mechanism of the reaction of papain with substrate-derived diazomethyl ketones. Implications for the difference in site specificity of halomethyl ketones for serine proteinases and cysteine…
- K. Brocklehurst, J. P. Malthouse
- ChemistryThe Biochemical journal
- 1 November 1978
TLDR
Reactions of papain and of low-molecular-weight thiols with some aromatic disulphides. 2,2'-Dipyridyl disulphide as a convenient active-site titrant for papain even in the presence of other thiols.
- K. Brocklehurst, G. Little
- Chemistry, BiologyThe Biochemical journal
- 1 May 1973
TLDR
Characterization of retinaldehyde dehydrogenase 3.
- C. Graham, K. Brocklehurst, R. Pickersgill, M. Warren
- Biology, ChemistryThe Biochemical journal
- 15 February 2006
TLDR
A necessary modification to the preparation of papain from any high-quality latex of Carica papaya and evidence for the structural integrity of the enzyme produced by traditional methods.
- Baldev S. Baines, K. Brocklehurst
- Chemistry, MedicineThe Biochemical journal
- 1 February 1979
A method of preparation of papain (EC 3.4.22.2) from relatively soluble types of latex of Carica papaya, including spray-dried latex produced by a controlled and relatively mild process, was devised.…
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