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Detection and Purification of Tyrosine-sulfated Proteins Using a Novel Anti-sulfotyrosine Monoclonal Antibody*
TLDR
Western blot analysis using PSG2 showed that certain sperm/epididymal proteins are undersulfated in Tpst2-/- mice, which indicates that TPST1 and TPST2 have distinct macromolecular substrate specificities and provides clues as to the molecular mechanism of the infertility of T pst 2-/- males. Expand
Detection of Homocysteine and C-Reactive Protein in the Saliva of Healthy Adults: Comparison with Blood Levels
TLDR
A relationship between CRP concentration in saliva and blood could not be established in this group of subjects and more sensitive detection methods are needed to determine if a correlation between salivary and serum homocysteine levels exists. Expand
Secondary Structure and Structure-Activity Relationships of Peptides Corresponding to the Subunit Interface of Herpes Simplex Virus DNA Polymerase*
TLDR
Using multidimensional 1H nuclear magnetic resonance spectroscopy, the 36-residue peptide contains partially ordered N- and C-terminal α-helices separated by a less ordered region that may aid in the rational design of new drugs for the treatment of herpesvirus infections. Expand
Salivary uric acid as a noninvasive biomarker of metabolic syndrome
TLDR
These results suggest that SUA may be a useful biomarker for noninvasive monitoring of cardiometabolic risk, and larger studies are needed to validate this approach. Expand
Identification of Crucial Hydrogen-Bonding Residues for the Interaction of Herpes Simplex Virus DNA Polymerase Subunits via Peptide Display, Mutational, and Calorimetric Approaches
TLDR
Interruption of these few bonds is sufficient to disrupt the interaction, suggesting that small molecules targeting the relevant side chains could interfere with Pol-UL42 binding. Expand
Use of the triglyceride to HDL cholesterol ratio for assessing insulin sensitivity in overweight and obese children in rural Appalachia
TLDR
Although females had higher insulin levels, male patients were significantly more likely to have hypertriglyceridemia and impaired fasting glucose and gender differences in the development of obesity-related metabolic abnormalities may impact the choice of screening studies in pediatric patients. Expand
Effects of Rib Raising on the Autonomic Nervous System: A Pilot Study Using Noninvasive Biomarkers
TLDR
The results of the present pilot study suggest that SNS activity may decrease immediately after rib raising, but the hypothalamic-pituitary-adrenal axis and parasympathetic activity are not altered by this technique. Expand
Synthesis and SAR of bis-statine based peptides as BACE 1 inhibitors.
TLDR
A new series of bis-statine based peptidomimetic inhibitors of human beta-secretase (BACE 1) was developed by structure-based modification of the three regions to the initial lead 3 by introducing a 4-aminomethylbenzoic acid on the C-terminus. Expand
A novel approach to identifying β-secretase inhibitors: Bis-statine peptide mimetics discovered using structure and spot synthesis
TLDR
The identification of novel "bis-statine" inhibitors shown by crystallography to have a unique binding mode demonstrates the application of peptide spot synthesis as an effective method for enhancing peptidomimetic drug discovery. Expand
Inappropriate Use of Homeostasis Model Assessment Cutoff Values for Diagnosing Insulin Resistance in Pediatric Studies
TLDR
Little evidence exists to support HOMA cutoff values commonly used to define insulin resistance in pediatric studies, and the importance of validating study design elements when training medical students and novice investigators is highlighted. Expand
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