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Cestode genomics – progress and prospects for advancing basic and applied aspects of flatworm biology
Characterization of the first tapeworm genome, Echinococcus multilocularis, is now nearly complete, and genome assemblies of E. granulosus, Taenia solium and Hymenolepis microstoma are in advancedExpand
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Axenic in vitro cultivation of Echinococcus multilocularis metacestode vesicles and the generation of primary cell cultures.
Parasitic helminths are a major cause of disease worldwide, yet the molecular mechanisms of host-helminth interaction and parasite development are only rudimentarily studied. A main reasons for thisExpand
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The unique stem cell system of the immortal larva of the human parasite Echinococcus multilocularis
BackgroundIt is believed that in tapeworms a separate population of undifferentiated cells, the germinative cells, is the only source of cell proliferation throughout the life cycle (similar to theExpand
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mRNA Trans-splicing in the Human Parasitic CestodeEchinococcus multilocularis *
An identical 36-nucleotide exon was identified at the 5′ termini of different mRNAs from the cestodeEchinococcus multilocularis. We provide evidence that this exon constitutes a new spliced leaderExpand
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Diversification of the insulin receptor family in the helminth parasite Schistosoma mansoni
Insulin signalling is a very ancient and well conserved pathway in metazoan cells, dependent on insulin receptors (IR) which are transmembrane proteins with tyrosine kinase activity. A unique IR isExpand
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Echinococcus multilocularis as an experimental model in stem cell research and molecular host-parasite interaction.
  • K. Brehm
  • Biology, Medicine
  • Parasitology
  • 1 March 2010
Totipotent somatic stem cells (neoblasts) are key players in the biology of flatworms and account for their amazing regenerative capability and developmental plasticity. During recent years,Expand
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Transient transfection of Echinococcus multilocularis primary cells and complete in vitro regeneration of metacestode vesicles.
A major limitation in studying molecular interactions between parasitic helminths and their hosts is the lack of suitable in vitro cultivation systems for helminth cells and larvae. Here we present aExpand
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Identification and molecular characterisation of a gene encoding a member of the insulin receptor family in Echinococcus multilocularis.
Receptor kinases play a key role in the communication of cells with their environment and could be important mediators of the effects of host cytokines on endoparasitic organisms. In this paper weExpand
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The role of evolutionarily conserved signalling systems in Echinococcus multilocularis development and host–parasite interaction
  • K. Brehm
  • Biology, Medicine
  • Medical Microbiology and Immunology
  • 8 April 2010
Alveolar echinococcosis, one of the most serious and life-threatening zoonoses in the world, is caused by the metacestode larval stage of the fox-tapeworm Echinococcus multilocularis. Mostly due toExpand
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Cytosine methylation is a conserved epigenetic feature found throughout the phylum Platyhelminthes
BackgroundThe phylum Platyhelminthes (flatworms) contains an important group of bilaterian organisms responsible for many debilitating and chronic infectious diseases of human and animal populationsExpand
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