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Estrogen can signal through multiple pathways to regulate oocyte cyst breakdown and primordial follicle assembly in the neonatal mouse ovary.
During mouse embryonic development, oocytes develop in germline cysts, formed by several rounds of cell division followed by incomplete cytokinesis. Shortly after birth, cysts break down and… Expand
Increase in extracellular NCAM and amyloid precursor protein following induction of long-term potentiation in the dentate gyrus of anaesthetized rats
The extracellular concentrations of the amyloid precursor protein (APP) and neural-cell adhesion molecule (NCAM) in the dentate gyrus of the anaesthetized rat were assayed before and after the… Expand
Intrauterine inflammation, insufficient to induce parturition, still evokes fetal and neonatal brain injury
- M. Elovitz, A. Brown, K. Breen, L. Anton, I. Burd
- International Journal of Developmental…
- 1 October 2011
Exposure to prenatal inflammation is a known risk factor for long term neurobehavioral disorders including cerebral palsy, schizophrenia, and autism. Models of systemic inflammation during pregnancy… Expand
Magnesium sulfate reduces inflammation-associated brain injury in fetal mice.
- I. Burd, K. Breen, A. Friedman, Jinghua Chai, M. Elovitz
- American journal of obstetrics and gynecology
- 1 March 2010
OBJECTIVE The purpose of this study was to investigate whether magnesium sulfate (MgSO(4)) prevents fetal brain injury in inflammation-associated preterm birth (PTB). STUDY DESIGN In a mouse model… Expand
TLR-4-Dependent and -Independent Mechanisms of Fetal Brain Injury in the Setting of Preterm Birth
- K. Breen, A. Brown, I. Burd, Jinghua Chai, A. Friedman, M. Elovitz
- Biology, Medicine
- Reproductive Sciences
- 23 July 2012
In this study, we sought to assess how essential activation of toll-like receptor 4 (TLR-4) is to fetal brain injury from intrauterine inflammation. Both wild-type and TLR-4 mutant fetal central… Expand
Sex-specific dysregulation of cysteine oxidation and the methionine and folate cycles in female cystathionine gamma-lyase null mice: a serendipitous model of the methylfolate trap
ABSTRACT In addition to its role in the endogenous synthesis of cysteine, cystathionine gamma-lyase (CGL) is a major physiological source of the vasorelaxant hydrogen sulfide. Cgl null mice are… Expand
Predator cues have contrasting effects on lifespan of Pardosa milvina (Araneae: Lycosidae)
Abstract Predators can affect prey indirectly by eliciting changes in behavior, morphology, and life history. These nonconsumptive effects are often mediated by predator cues used by prey to avoid… Expand
Tumor testing in men with prostate cancer to predict for germline DNA-damage repair mutations.
229Background: Current guidelines recommend genetic testing for patients (pts) who have BRCA1/2 mutations on tumor-only testing, where germline is not subtracted. The clinical utility of this appro...
638: Unraveling the mechanisms leading to increased maternal mortality from systemic illness