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Novelty acquisition is associated with induction of hippocampal long-term depression.
Observations strongly implicate an association between novelty acquisition and LTD, and LFS given during exploration of a novel environment resulted in LTD expression in Hooded Lister, and LTD enhancement in Wistar, rats.
The Neuronal Calcium Sensor Protein VILIP-1 Is Associated with Amyloid Plaques and Extracellular Tangles in Alzheimer's Disease and Promotes Cell Death and Tau Phosphorylation in Vitro: A Link
The results raise the possibility that the observed reduction in VILIP-1-expressing cells may indicate a selective vulnerability of these neurons and that the calcium sensor protein is involved in the pathophysiology of Alzheimer's disease.
Intracellular neuronal calcium sensor proteins: a family of EF-hand calcium-binding proteins in search of a function
This review focuses on calcium-dependent membrane association by the so-called calcium-myristoyl switch as a possible mechanism of signal transduction and on the roles of NCS proteins in intraneuronal signaling cascades, which are best studied in the visual and olfactory systems.
Long-Term Depression: A Cellular Basis for Learning?
This review focuses on the interpretation of novel and established information with regard to LTD in the hippocampal CA1 region in terms of its possible role as a cellular basis for learning and memory.
Functional Involvement of Sciatic Nerve‐derived Versicanand Decorin‐like Molecules and other Chondroitin Sulphate Proteoglycans in ECM‐mediated Cell Adhesion and Neurite Outgrowth
Observations suggest that binding of the two proteoglycans to fibonectin is involved in the modulation of adhesion of cells to fibronectin.
Abnormal Localization of Two Neuronal Calcium Sensor Proteins, Visinin-Like Proteins (VILIPs)-1 and -3, in Neocortical Brain Areas of Alzheimer Disease Patients
The anatomical distribution of the neuronal calcium sensor proteins visinin-like protein-1 and -3 (VILIP-1 and -3) was investigated in various neocortical areas of Alzheimer’s disease (AD) patients
The metabotropic glutamate receptor, mGluR5, is a key determinant of good and bad spatial learning performance and hippocampal synaptic plasticity.
Striking mGluR5-dependent differences in spatial learning in different rat strains are revealed, which correlate to synaptic plasticity and mGLUR5 expression levels.
Visinin-like proteins (VSNLs): interaction partners and emerging functions in signal transduction of a subfamily of neuronal Ca2+-sensor proteins
VSNLs play neuroprotective and neurotoxic roles and have been implicated in neurodegenerative diseases, and are involved in differentiation processes showing a tumor-invasion-suppressor function in peripheral organs.