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Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA
Methicillin-resistant Staphylococcus aureus (MRSA) remains a major human pathogen. Traditionally, MRSA infections occurred exclusively in hospitals and were limited to immunocompromised patients orExpand
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  • Open Access
Evolution of virulence in epidemic community-associated methicillin-resistant Staphylococcus aureus
  • M. Li, B. Diep, +6 authors M. Otto
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 7 April 2009
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has recently emerged worldwide. The United States, in particular, is experiencing a serious epidemic of CA-MRSA that isExpand
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Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease?
Methicillin-resistant Staphylococcus aureus (MRSA) remains a major problem in hospitals, and it is now spreading in the community. A single toxin, Panton-Valentine leukocidin (PVL), has been linkedExpand
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Epidemic community-associated methicillin-resistant Staphylococcus aureus: Recent clonal expansion and diversification
Emerging and re-emerging infectious diseases, especially those caused by drug-resistant bacteria, are a major problem worldwide. Community-associated methicillin-resistant Staphylococcus aureusExpand
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  • Open Access
Polysaccharide intercellular adhesin (PIA) protects Staphylococcus epidermidis against major components of the human innate immune system
The skin commensal and opportunistic pathogen Staphylococcus epidermidis is the leading cause of nosocomial and biofilm‐associated infections. Little is known about the mechanisms by which S.Expand
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Insights into Mechanisms Used by Staphylococcus aureus to Avoid Destruction by Human Neutrophils1
Polymorphonuclear leukocytes (PMNs, or neutrophils) are critical for human innate immunity and kill most invading bacteria. However, pathogens such as Staphylococcus aureus avoid destruction by PMNsExpand
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Polymorphonuclear leukocytes mediate Staphylococcus aureus Panton-Valentine leukocidin-induced lung inflammation and injury
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is epidemic in the United States, even rivaling HIV/AIDS in its public health impact. The pandemic clone USA300, like otherExpand
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  • Open Access
Global Changes in Staphylococcus aureus Gene Expression in Human Blood
Staphylococcus aureus is a leading cause of bloodstream infections worldwide. In the United States, many of these infections are caused by a strain known as USA300. Although progress has been made,Expand
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  • Open Access
Staphylococcus epidermidis Strategies to Avoid Killing by Human Neutrophils
Staphylococcus epidermidis is a leading nosocomial pathogen. In contrast to its more aggressive relative S. aureus, it causes chronic rather than acute infections. In highly virulent S. aureus,Expand
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Bacterial pathogens modulate an apoptosis differentiation program in human neutrophils
Human polymorphonuclear leukocytes (PMNs or neutrophils) are essential to the innate immune response against bacterial pathogens. Recent evidence suggests that PMN apoptosis facilitates resolution ofExpand
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