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Lipoprotein-like particles and cholesteryl esters in human Bruch's membrane: initial characterization.
PURPOSE To isolate and characterize cholesteryl ester-containing, lipoprotein-like particles (LLPs) from normal aged human Bruch's membrane (BrM)/choroid (Ch). METHODS From BrM/Ch of 20 eyes of 10Expand
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Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia
Necroptosis is a highly pro-inflammatory mode of cell death regulated by RIP (or RIPK)1 and RIP3 kinases and mediated by the effector MLKL. We report that diverse bacterial pathogens that produce aExpand
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Tractional force generation by human müller cells: growth factor responsiveness and integrin receptor involvement.
PURPOSE To assess the ability of human Müller cells to generate tractional forces and to determine the role of growth factors and collagen binding integrins in this process. METHODS Müller cellsExpand
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Pore-forming toxin-mediated ion dysregulation leads to death receptor-independent necroptosis of lung epithelial cells during bacterial pneumonia
We report that pore-forming toxins (PFTs) induce respiratory epithelial cell necroptosis independently of death receptor signaling during bacterial pneumonia. Instead, necroptosis was activated as aExpand
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Administration of nitrite after chlorine gas exposure prevents lung injury: effect of administration modality.
Cl(2) gas toxicity is complex and occurs during and after exposure, leading to acute lung injury (ALI) and reactive airway syndrome (RAS). Moreover, Cl(2) exposure can occur in diverse situationsExpand
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Quercetin induced tissue‐type plasminogen activator expression is mediated through Sp1 and p38 mitogen‐activated protein kinase in human endothelial cells
Summary.  Background: Wine polyphenol quercetin upregulates tissue‐type plasminogen activator (t‐PA) transcription in cultured human umbilical cord vein endothelial cells (HUVECs). However, theExpand
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Bacterial Pore-Forming Toxins Promote the Activation of Caspases in Parallel to Necroptosis to Enhance Alarmin Release and Inflammation During Pneumonia
Pore-forming toxins are the most common virulence factor in pathogenic bacteria. They lead to membrane permeabilization and cell death. Herein, we show that respiratory epithelial cells (REC)Expand
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Mechanism by which alcohol and wine polyphenols affect coronary heart disease risk.
The reduction in coronary heart disease (CHD) from moderate alcohol intake may be mediated, in part, by increased fibrinolysis; endothelial cell (EC)-mediated fibrinolysis should decrease acuteExpand
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Chlorine gas exposure causes systemic endothelial dysfunction by inhibiting endothelial nitric oxide synthase-dependent signaling.
Chlorine gas (Cl(2)) exposure during accidents or in the military setting results primarily in injury to the lungs. However, the potential for Cl(2) exposure to promote injury to the systemicExpand
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A Randomized Clinical Trial Testing the Anti-Inflammatory Effects of Preemptive Inhaled Nitric Oxide in Human Liver Transplantation
Decreases in endothelial nitric oxide synthase derived nitric oxide (NO) production during liver transplantation promotes injury. We hypothesized that preemptive inhaled NO (iNO) would improveExpand
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