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The Arabidopsis thaliana Med25 mediator subunit integrates environmental cues to control plant development
TLDR
This work shows that a linear 130-amino-acids-long sequence in the Med25 subunit of the Arabidopsis thaliana Mediator is a common target for the drought response element binding protein 2A, zinc finger homeodomain 1, and Myb-like transcription factors which are involved in different stress response pathways. Expand
Structural basis of signal-sequence recognition by the signal recognition particle
TLDR
Structural comparison with the free SRP core shows that signal-sequence binding induces formation of the GM-linker helix and a 180° flip of the NG domain—structural changes that ensure a hierarchical succession of events during protein targeting. Expand
Properties of RNA Polymerase Bypass Mutants
TLDR
Analysis of five hyper-suppressor mutants within the β- and β′-subunits of core RNA polymerase that allow high levels of transcription from the σ54-Po promoter in the absence of ppGpp suggests that stringent regulation is a key mechanism by which the activity of alternative σ-factors is controlled to meet cellular requirements. Expand
Promiscuous Cross-seeding between Bacterial Amyloids Promotes Interspecies Biofilms*
TLDR
The results showed that curli subunit homologs from Escherichia coli, Salmonella typhimurium LT2, and Citrobacter koseri were able to cross-seed in vitro and this work suggests that the seeding specificity among curli Homologs is relaxed and that heterogeneous curli fibers can facilitate multispecies biofilm development. Expand
The Schistosoma mansoni Protein Sm16/SmSLP/SmSPO-1 Assembles into a Nine-Subunit Oligomer with Potential To Inhibit Toll-Like Receptor Signaling
TLDR
The strategy behind the design of a modified Sm16protein with a decreased aggregation propensity is described, thus facilitating the expression and purification of an Sm16 protein that is soluble in physiological buffers and indicates that inhibition is exerted proximal to the TLR complex. Expand
Pro-inflammatory cytokines can act as intracellular modulators of commensal bacterial virulence
TLDR
It is shown that the human pathogen Neisseria meningitidis, the leading cause of pyogenic meningitis, can modulate gene expression via uptake of host pro-inflammatory cytokines leading to increased virulence. Expand
The C-terminal repeating units of CsgB direct bacterial functional amyloid nucleation.
TLDR
The results suggest a model where the rapid conversion of CsgB from unstructured protein to a β-sheet-rich amyloid template anchored to the cell surface is mediated by the C-terminal repeating units. Expand
Aneugenic activity of Op18/stathmin is potentiated by the somatic Q18-->e mutation in leukemic cells.
TLDR
Although Op18 is dispensable for mitosis, the hyperactive Q18-->E mutant, or overexpressed wild-type Op18, exerts aneugenic effects that are likely to contribute to chromosomal instability in tumors. Expand
Diversity in Overall Activity Regulation of Ribonucleotide Reductase*
TLDR
It is shown that the Pseudomonas aeruginosa class I RNR has a duplicated ATP cone domain and represents a third mechanism of overall activity regulation, which is unique among RNRs. Expand
Structural Insights into Polymorphic ABO Glycan Binding by Helicobacter pylori.
TLDR
X-ray structures of representative BabA isoforms are generated that reveal a polymorphic, three-pronged Le(b) binding site, and high sequence variation causes BabA functional diversity, but the underlying structural-molecular determinants are unknown. Expand
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