• Publications
  • Influence
Group-B streptococcal infections.
TLDR
Group B Streptococcus (GBS) has become the major cause of bacterial infections in the perinatal period, including bacteremia, amnionitis, endometritis, and urinary tract infection in pregnant women as well as focal and systemic infections in newborns.
Selective intrapartum chemoprophylaxis of neonatal group B streptococcal early-onset disease. II. Predictive value of prenatal cultures.
TLDR
Density of colonization, however, strongly influenced rates of vertical transmission to neonates and rates of heavy infant colonization, and density of colonization at parturition was not predicted by the sites of prenatal colonization.
Early and Longitudinal Evaluations of Treated Infants and Children and Untreated Historical Patients with Congenital Toxoplasmosis: The Chicago Collaborative Treatment Trial
TLDR
Most remarkable were the normal developmental, neurological, and ophthalmologic findings at the early follow-up evaluations of many--but not all--of the treated children despite severe manifestations, such as substantial systemic disease, hydrocephalus, microcephalus and multiple intracranial calcifications, and extensive macular destruction detected at birth.
Unrecognized ingestion of Toxoplasma gondii oocysts leads to congenital toxoplasmosis and causes epidemics in North America.
TLDR
Only a vaccine or implementation of systematic serologic testing of pregnant women and newborns, followed by treatment, will prevent most congenital toxoplasmosis in North America.
Identification of a Sporozoite-Specific Antigen from Toxoplasma gondii
TLDR
Data suggest that TgERP may be useful in detecting exposure to sporozoites in early T. gondii infection and implicates oocysts as the agent of infection.
Tick-borne relapsing fever: an interstate outbreak originating at Grand Canyon National Park.
TLDR
This outbreak, the largest yet identified in North America, extends the known range of a principal vector and establishes the North Rim as an endemic source of tick-borne relapsing fever.
Prematurity and severity are associated with Toxoplasma gondii alleles (NCCCTS, 1981-2009).
TLDR
Type II and NE-II parasites cause congenital toxoplasmosis in North America and type II was more prevalent in certain demographics and associated with prematurity and severe disease at birth and both type II andNE-II infections improved with treatment.
Selective intrapartum chemoprophylaxis of neonatal group B streptococcal early-onset disease. III. Interruption of mother-to-infant transmission.
TLDR
Ampicillin treatment was associated with a highly significant reduction in maternal postpartum vaginal colonization by GBS and virtually eliminated vertical transmission in the treatment group with no risk factors and in both treatment groups with premature labor and/or prolonged membrane rupture.
...
...