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The Human Transcriptome Map: Clustering of Highly Expressed Genes in Chromosomal Domains
The chromosomal position of human genes is rapidly being established. We integrated these mapping data with genome-wide messenger RNA expression profiles as provided by SAGE (serial analysis of geneExpand
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In utero supplementation with methyl donors enhances allergic airway disease in mice.
Asthma is a complex heritable disease that is increasing in prevalence and severity, particularly in developed countries such as the United States, where 11% of the population is affected. TheExpand
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N‐myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis
The myc oncogenes are frequently activated in human tumors, but there is no comprehensive insight into the target genes and downstream cellular pathways of these transcription factors. We appliedExpand
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UTF1, a novel transcriptional coactivator expressed in pluripotent embryonic stem cells and extra‐embryonic cells
We have obtained a novel transcriptional cofactor, termed undifferentiated embryonic cell transcription factor 1 (UTF1), from F9 embryonic carcinoma (EC) cells. This protein is expressed in EC andExpand
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The MEIS1 oncogene is highly expressed in neuroblastoma and amplified in cell line IMR32.
Neuroblastoma is an embryonal tumor originating from neural crest-derived cells. Here we present the serendipitous cloning of amplified sequences of chromosome 2p15 in neuroblastoma cell line IMR32.Expand
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Rearrangements and increased expression of cyclin D1 (CCND1) in neuroblastoma
Cyclin D1 regulates G1 cell cycle progression by controlling the phosphorylation of the retinoblastoma protein. This pathway is frequently deregulated in many malignancies. In neuroblastoma, however,Expand
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The N-myc and c-myc downstream pathways include the chromosome 17q genes nm23-H1 and nm23-H2
Gain of chromosome 17q material is the most frequent genetic abnormality in neuroblastomas. The common region of gain is at least 375 cR large, which has precluded the identification of genes with aExpand
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In utero supplementation with methyl donors enhances allergic airway disease in mice.
Asthma is a complex heritable disease that is increasing in prevalence and severity, particularly in developed countries such as the United States, where 11% of the population is affected. TheExpand
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Evaluating genome-wide DNA methylation changes in mice by Methylation Specific Digital Karyotyping
BackgroundThe study of genome-wide DNA methylation changes has become more accessible with the development of various array-based technologies though when studying species other than human the choiceExpand
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Abstract LB-140: An innovative approach for profiling of histone modification marks and gene expression across a panel of oncogenes and tumor suppressor genes in multiple cancer cell lines
Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC Objectives: Histone modification marks and gene expression profiling on multiple human oncogenes and tumor suppressorExpand