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Nestin expression – a property of multi-lineage progenitor cells?
TLDR
It is shown that nestin is abundant in ES-derived progenitor cells that have the potential to develop into neuroectodermal, endodermal and mesodermal lineages and suggested that its presence in cells may indicate multi-potentiality and regenerative potential.
AGEMAP: A Gene Expression Database for Aging in Mice
TLDR
The AGEMAP (Atlas of Gene Expression in Mouse Aging Project) gene expression database is presented, which is a resource that catalogs changes in gene expression as a function of age in mice and finds great heterogeneity in the amount of transcriptional changes with age in different tissues.
Differentiation of Pluripotent Embryonic Stem Cells Into Cardiomyocytes
TLDR
This review summarizes the current state of ES cell–derived cardiogenesis and provides an overview of how genomic strategies coupled with this in vitro differentiation system can be applied to cardiac research.
Embryonic stem cells: prospects for developmental biology and cell therapy.
TLDR
This review focuses both on mouse and human ES cells with respect to in vitro propagation and differentiation as well as their use in basic cell and developmental biology and toxicology and presents prospects forhuman ES cells in tissue regeneration and transplantation.
Local Control Models of Cardiac Excitation–Contraction Coupling
TLDR
It was possible to restore stability to a model based on a bilayer-derived gating scheme, by introducing allosteric interactions between nearest-neighbor RyRs so as to stabilize the inactivated state and produce cooperativity among calcium binding sites on different RyRs.
A Mass Spectrometric-Derived Cell Surface Protein Atlas
Cell surface proteins are major targets of biomedical research due to their utility as cellular markers and their extracellular accessibility for pharmacological intervention. However, information
Patterns of expression of sarcoplasmic reticulum Ca(2+)-ATPase and phospholamban mRNAs during rat heart development.
TLDR
This study reports the clonal analysis and sequence of rat phospholamban (PLB) cDNA clones and the temporal appearance and patterns of distribution of the mRNAs encoding SERCA2 and PLB in the developing rat heart determined by in situ hybridization.
Altered sarcoplasmic reticulum Ca2(+)-ATPase gene expression in the human ventricle during end-stage heart failure.
TLDR
It is suggested that a decrease of the SR Ca2(+)-ATPase mRNA in the myocardium plays an important role in alterations of Ca2+ movements and myocardial relaxation reported during human end-stage heart failure.
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