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Characterization of voltage-gated calcium currents in freshly isolated smooth muscle cells from rat tail main artery.
It is shown that smooth muscle cells freshly isolated from rat tail main artery may be divided into two populations, one expressing both L- and T- type and the other only L-type Ca2+ channels, and cinnarizine potently inhibited T-type currents at low concentrations but also blocked L- type Ca2+.
Cyclopiazonic acid-induced changes in contractile activity of smooth muscle strips isolated from cat and guinea-pig stomach.
  • G. Petkov, K. Boev
  • Biology, Medicine
    European journal of pharmacology
  • 27 December 1996
Multiple roles are suggested for sarcoplasmic reticulum Ca2+ stores and sarcoplastikulum Ca(2+)-ATPase in the shaping of spontaneous and evoked tonic and phasic contractions of the stomach, and highlight important species and tissue differences.
Role of constitutively expressed heme oxygenase-2 in the regulation of guinea pig coronary artery tone
Results suggest that the constitutive HO-2 in coronary artery smooth muscle cells plays role in the modulation of tone.
L-type calcium channels may fill directly the IP3-sensitive calcium store.
The inhibition of the latter in heparin-loaded cells from the longitudinal layer is supposed to be Ca(2+)-dependent due to the overfilling of the inositol-1,4,5-trisphosphate-sensitive Ca2+ store.
Two types of Ca(2+)-channels in cells from the circular layer of guinea-pig ileum.
Data suggest the coexistence of T- and L-types calcium channels in CC, and the participation of If in the total inward current of CC was deduced from the presence of a low-threshold "hump" in the current-voltage relation curve.
Myorelaxant activity of 2-t-butyl-4-methoxyphenol (BHA) in guinea pig gastric fundus.
The myorelaxant action of BHA on gastric fundus smooth muscle appears to be mediated partly by an increase in cAMP levels and partly by inhibition of Ca2+ influx from the extracellular space.
Ca2+-induced Ca2+ release activates K+ currents by a cyclic GMP-dependent mechanism in single gastric smooth muscle cells
Abstract The participation of sarcoplasmic reticulum Ca 2+ release channels in the activation of Ca 2+ -sensitive K + currents ( I K(Ca) ) by cyclic dibutyryl GMP was investigated in smooth muscle
Role of sarcoplasmic reticulum in the myorelaxant activity of nitric oxide donors in guinea pig gastric fundus.
The results suggest that NO, released from NO donors increases the sarcoplasmic reticulum Ca2+ uptake thereby enhancing the vectorial sarcoplasmsic ReticulumCa2+ release toward the plasmalemma to elicit membrane hyperpolarization and relaxation in guinea pig gastric fundus.
Ionic currents in the somatic membrane of identified T-mechanosensory neurons isolated from segmental ganglia of the medicinal leech.
The methods of intracellular perfusion and voltage-clamp were applied to study the ionic mechanisms of excitability of the somatic membrane of leech neuron under controlled external and internal ionic conditions.
Cyclic GMP-induced activation of potassium currents by sarcoplasmic reticulum Ca2+ pump-dependent mechanism.
The authors' data suggest that, in gastric fundus smooth muscles, NO-liberating substances and cGMP analogues contribute to the activation of a Ca2+ -release mechanism from the cell bulk, i.e. the myoplasm surrounding the contractile filaments, towards the plasma membrane, crossing the SR Ca2-stores.