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5 Glutamate Dehydrogenases
This chapter discusses the types of investigations with major emphasis on recent studies that include elucidation of complete or partial amino acid sequences of the enzymes from several sources, and the successful isolation from some species of modified forms of the enzyme produced by mutant strains, particularly of Neurospora. Expand
The Tarantula Toxins ProTx-II and Huwentoxin-IV Differentially Interact with Human Nav1.7 Voltage Sensors to Inhibit Channel Activation and Inactivation
Whereas ProTx-II and HW TX-IV binding determinants on domain-II may overlap, domain II plays a much more crucial role for HWTX-IV, and contrary to what has been proposed to be a guiding principle of sodium channel pharmacology, molecules do not have to exclusively target the domain IV voltage-sensor to influence sodium channel inactivation. Expand
Molecular interactions of the gating modifier toxin ProTx-II with NaV 1.5: implied existence of a novel toxin binding site coupled to activation.
The data establish that, contrary to prior assumptions, ProTx-II does not bind to the previously characterized neurotoxin site 4, thus making it a novel probe of activation gating in Na(v) channels with potential to shed new light on this process. Expand
AnkB, a periplasmic ankyrin-like protein in Pseudomonas aeruginosa, is required for optimal catalase B (KatB) activity and resistance to hydrogen peroxide.
The cloned ankB gene, encoding an ankyrin-like protein in Pseudomonas aeruginosa, is cloned and it is suggested that AnkB may form an antioxidant scaffolding with KatB in the periplasm at the cytoplasmic membrane, thus providing a protective lattice work for optimal H( 2)O(2) detoxification. Expand
ProTx-I and ProTx-II: gating modifiers of voltage-gated sodium channels.
ProTx-I and ProTx-II inhibit all sodium channel (Nav1) subtypes tested with similar potency and represent the first potent peptidyl inhibitors of TTX-resistant sodium channels. Expand
A Specific Interaction between the Cardiac Sodium Channel and Site-3 Toxin Anthopleurin B*
The polypeptide neurotoxin anthopleurin B (ApB) isolated from the venom of the sea anemone Anthopleura xanthogrammica is one of a family of toxins that bind to the extracellular face ofExpand
Site-3 sea anemone toxins: molecular probes of gating mechanisms in voltage-dependent sodium channels.
Sea anemone toxins, whose biological function is the capture of marine prey, are invaluable tools for studying the structure and function of mammalian voltage-gated sodium channels. Their high degreeExpand
High Affinity Dimerization by Ski Involves Parallel Pairing of a Novel Bipartite α-Helical Domain*
c-Ski protein possesses a C-terminal dimerization domain that was deleted during the generation of v-ski, and has been implicated in the increased potency of c-ski in cellular transformation comparedExpand
Differential Phospholipid Binding by Site 3 and Site 4 Toxins
It is concluded that toxins that modify inactivation kinetics via binding to NaV1.x site 3 lack the ability to bind phospholipids, whereas site 4 toxins, which modify activation, have this activity. Expand
Persistent Regional Downregulation in Mitochondrial Enzymes and Upregulation of Stress Proteins in Swine With Chronic Hibernating Myocardium
Hibernating myocardium developed a significant downregulation of many mitochondrial proteins and an upregulation of stress proteins that may limit oxidative injury and apoptosis and impact functional recovery after revascularization. Expand