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Simultaneous determination of pioglitazone and glimepiride in bulk drug and pharmaceutical dosage form by RP-HPLC method.
  • K. A, S. G, +6 authors U. N.
  • Chemistry, Medicine
  • Pakistan journal of pharmaceutical sciences
  • 1 October 2008
A simple, fast, and precise reverse phase, isocratic HPLC method was developed for the separation and quantification of pioglitazone and glimepiride in bulk drug and pharmaceutical dosage form and is suitable for simultaneous determination. Expand
Preparation and characterization of co-amorphous Ritonavir-Indomethacin systems by solvent evaporation technique: improved dissolution behavior and physical stability without evidence of
The study demonstrated significant increase in the dissolution rate as well as increased in the total amount of drug dissolved for amorphous RTV, however it failed to demonstrate any significant improvement in the dissolve behavior of IND. Expand
LC determination and pharmacokinetics of meloxicam.
A simple and rapid HPLC assay method for the estimation of meloxicam in plasma was developed and was also used for the bioequivalence study ofmeloxicam formulation in healthy, human, Indian, male volunteers. Expand
Enhanced oral absorption of saquinavir with Methyl-Beta-Cyclodextrin-Preparation and in vitro and in vivo evaluation.
The study reveals that the integrated approach of pH adjustment and CyD complexation can be successfully used for improving the CyD solubilizing power towards an ionizable drug such as SQV, thus allowing a smaller quantity of CyD tosolubilize a given amount of drug, offering clear economic and technologic advantages as well. Expand
Development and Validation of Liquid Chromatographic Method for Estimation of Naringin in Nanoformulation
The proposed liquid chromatographic method was successfully employed for the routine analysis of said compound in developed novel nanopharmaceuticals and the presence of excipients did not show any interference on the determination of NAR, indicating method specificity. Expand
Fabrication, solid state characterization and bioavailability assessment of stable binary amorphous phases of Ritonavir with Quercetin.
In the current study, Quercetin (QRT) was characterized for thermodynamic and kinetic parameters and found as an excellent glass former and paired with Ritonavir (RTV) to form stable amorphous form and pharmacologically relevant combination. Expand
Low frequency ultrasound and PAMAM dendrimer facilitated transdermal delivery of ketoprofen
Abstract The aim of the present study was to investigate the combined effect of PAMAM dendrimers and low-frequency ultrasound on the transdermal delivery of ketoprofen. Ketoprofen was subjected to inExpand
A sensitive and selective HPLC method for estimation of lamotrigine in human plasma and saliva: application to plasma-saliva correlation in epileptic patients.
A sensitive and selective high performance liquid chromatographic (HPLC) method was developed and validated for estimation of lamotrigine in human plasma and saliva and showed a gold linear relationship between them. Expand
Estimation and pharmacokinetics of metformin in human volunteers
A simple and rapid HPLC assay method for the estimation of metformin in human plasma was developed and validated. The method totally eliminates the extraction procedure. The plasma proteins wereExpand
Development and validation of stability indicating HPLC method for Clotrimazole lozenges formulation
Objective: A simple, sensitive, precise and accurate stability-indicating HPLC method has been developed and validated for determination of Clotrimazole (CLOT) in its lozenges dosage form. Methods:Expand